As a specialist in scientific information solutions, CAS is partnering with research organizations around the globe to tackle the rapidly evolving and complex challenge of COVID-19. Aligned with our mission as a division of the American Chemical Society, CAS is making a wide range of resources and expertise openly available to support this fight. If customized support from CAS scientists and technologists would be valuable to augment your COVID-19 research efforts, we welcome your outreach to the CAS Customer Center.
QSAR Machine Learning Models and their Applications for Identifying Potential COVID-19 Therapeutics
To identify potential anti-SARS-CoV-2 therapeutics, CAS scientists are building machine-learning predictive models to identify novel drug candidates for the viral targets 3 chymotrypsin-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp).
Potential Therapeutics and Associated Bioassay Data for COVID-19
To support ongoing research and development of COVID-19 therapeutics, this report provides an overview of protein targets and corresponding potential drug candidates with bioassay and structure-activity relationship data found in the scientific and patent literature for COVID-19.
CAS COVID-19 Bioindicator Explorer
The CAS COVID-19 Bioindicator Explorer uses data extracted from our comprehensive journal and patent collection to identify correlations between drug-like substances with antiviral activity and COVID-19 protein targets.
CAS COVID-19 Antiviral Candidate SAR Dataset
This open source dataset contains over 290K structure-activity relationship (SAR) data directed at COVID-19 protein, virus and disease targets reported in the literature, patents, and other public sources for over 9K of the substances included in the CAS COVID-19 Antiviral Candidate Compounds Dataset.
Assay Techniques and Test Development for COVID-19 Diagnosis
To provide an understanding and comparison of the diagnostic tests available in the fight against COVID-19, this CAS report summarizes the basic principles of molecular and serological assays being used in diagnostic tests for SARS-CoV-2. The report highlights advancements in testing technologies and provides a look at currently available diagnostic tests.
CAS COVID-19 Protein Target Thesaurus
This collection of human-curated protein targets and their synonyms from CAS REGISTRY® and the CAS Thesaurus provides additional points of discovery to supplement your research.
CAS COVID-19 Antiviral Candidate Dataset
The open source dataset of nearly 50K chemical substances includes antiviral drugs and related compounds that are structurally similar to known antivirals for use in applications including research, data mining, machine learning, and analytics.
Open Access Article: R&D of Therapeutics and Vaccines of COVID-19 and related diseases
This CAS special report provides a comprehensive overview of published scientific information highlighting antiviral strategies involving small molecules and biologics targeting complex molecular interactions. Published in ACS Central Science.