CAS Connections brings the CAS Content Collection™ and CAS Newton℠ agentic AI directly into your existing research platforms, AI environments, and agentic workflows — so the science your organization depends on is available wherever decisions are made.
Every extra step between a researcher and reliable scientific information is a gap where discovery stalls. Fragmented access to scientific knowledge introduces risk into AI-generated answers and forces researchers to choose between the tools they know and the information they need.
Authoritative chemical and biological knowledge surfaces earlier in the process - right when your researchers need it.
AI answers grounded in curated, verifiable scientific sources so every recommendation can be cited and defended.
Traceable access to CAS content within your enterprise workflow solutions — consistent with the rigorous standards pharma and chemical R&D requires.
Reduce repeated searches and manual data transfer across systems — researchers stay focused on science.
What CAS Connections delivers
CAS Connections embeds CAS content and CAS Newton agentic AI into your existing tools.Every integration draws on the full depth of our trusted, curated scientific knowledge.
Data Access
Query CAS content programmatically. Responses feed directly into ELNs, LIMS, and more — giving you structured, reliable data delivered at the point of decision.
AI Integration
CAS Newton connects as a knowledge source inside existing AI platforms, so the intelligence powering those tools is grounded in curated, citable content.
Need more?
For organizations whose needs go beyond CAS Connections , CAS Custom Services builds purpose-built solutions around your environment.
License CAS AI-ready data
Integrate CAS content directly into your internal workflows via API, MCP or CAS Newton
Make your own data AI-ready
Growing systems
CAS Connections is expanding across the R&D software landscape. The platform investments your organization has already made become more valuable with CAS content and AI available inside them.
Read the announcement →
Who it serves
Prior art, synthesis routes, safety data, and reaction history surface directly within ELNs, LIMS, and discovery platforms with minimal interruptions or separate lookups.
Query CAS content programmatically via API. Feed curated scientific data directly into models, dashboards, and analytical workflows combined with your organization's proprietary data in a secure environment.
CAS Newton provides agent-to-agent interaction via MCP to deliver verified, cited scientific intelligence to AI systems mid-workflow. As your AI ecosystem evolves, CAS evolves with it.
The content behind it
Over 150 years of human-curated scientific knowledge now available in select partner platforms. Looking for other ways to integrate CAS content? CAS Custom Services can help.
300M+ substances, uniquely identified.
Synthesis routes and reaction data, searchable by structure.
Scientific literature across chemistry, biology, and pharmacology — curated since 1907.
Patent data linked to substances and sequences — supporting FTO and IP workflows.
Security and Trust
CAS Connections is designed to meet the security and compliance expectations of enterprise R&D with the controls and auditability that give IT, legal, and research leadership confidence in every integration.
Powered by CAS Newton
CAS Newton is built for scientific reasoning. It handles complex, multi-part research questions and returns cited, verifiable answers grounded in the CAS Content Collection. Through CAS Connections, that same capability runs within partner platforms, held to the same standards of accuracy and auditability your organization requires.
Learn about CAS Newton →Talk to a CAS specialist about integrating CAS Connections into your organization's existing ELNs, LIMS, and LLNs with select CAS partners.
Frequently asked questions
CAS Connections is how organizations embed CAS content and capabilities directly into the tools, platforms, and workflows their teams already use via pre-built connectors available through a growing ecosystem of CAS partner platforms — covering ELNs, LIMS, discovery tools, and AI platforms.
Direct API MCP access for customers building their own integrations is available through CAS Custom Services. CAS Newton integration into your own environment is also available through CAS Custom Services. Every path draws on the CAS Content Collection and CAS Newton agentic AI.
CAS Connections offers integrations across a growing set of partner platforms spanning laboratory informatics, AI-assisted discovery, and materials science, with additional platforms to be announced throughout 2026.
CAS Connections can surface content from across the CAS Content Collection — including CAS REGISTRY, CAS Reactions, CAS References, and CAS Patents. The specific content accessible through a given integration depends on your organization's existing CAS subscriptions and the partner platform's configuration.
CAS Connections deploys via the existing, secure infrastructure of trusted third-party platforms your organization already accesses.
Access to CAS content through CAS Connections is governed by your organization's CAS subscriptions. Existing CAS customers can work with their account team to understand what partner platform connections available and how to enable integrations. If you are new to CAS, contact us to discuss the right starting point.
For organizations with needs beyond what CAS Connections covers, including direct access to the CAS Content Collection via API, MCP, or CAS Newton, structuring and integration of proprietary R&D data, or custom AI/ML deployment — CAS Custom Services delivers purpose-built solutions scoped to your environment. Learn about CAS Custom Services →