Agentic AI grounded in trusted science
CAS Newton enables conversational scientific discovery. Ask complex, multi-part questions and receive context-based, cited answers sourced from 150+ years of curated and human-verified science found in the CAS Content Collection™, making CAS Newton the best agentic AI for science.
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When getting the science wrong isn’t an option, can you trust your AI?
When stakes are highest, you need answers that can be sourced and defended. Most AI tools were built for language, but CAS Newton is built on over 150 years of peer-reviewed scientific literature that is curated by CAS scientists and interconnected across disciplines. Every answer is sourced and cited so you can verify.
3 out of 4
Early users rated CAS Newton answers as more trustworthy than those from other AI tools
From question to discovery
CAS Newton does not just retrieve information. It reasons through it, connects it, and returns answers you can act on immediately.
A trusted scientific foundation
Every answer is grounded in the CAS Content Collection™, curated and refined by CAS scientists. Get conclusions you can stand behind because the evidence behind every output is authoritative, verifiable, and citable.
Science that goes deeper
Complex, multi-part questions become targeted search paths across chemistry, biology, and more. Science-specific capabilities including structure search, functional group reactivity, spectra prediction, and properties prediction surface what a standard search cannot reach.
Complex research that moves faster
Multi-step research workflows run autonomously. Vast reference sets become clear, actionable direction. As findings emerge, hidden relationships and trends surface across the CAS Content Collection without requiring you to manually piece results together.
Decisions you can stand behind
Get the evidence to generate hypotheses, validate assumptions, and support competitive analysis and trend identification. Verified scientific evidence sits behind every recommendation, so every decision your organization makes is defensible.
Integrated into your workflow
CAS Newton, everywhere you work
CAS Newton is available within trusted CAS solutions like CAS SciFinder®, CAS BioFinder®, and CAS IP Finder, powered by STN™. You can also experience the possibilities CAS Newton delivers in other workflow tools via CAS Connections℠.
CAS Newton in CAS SciFinder
Agentic Search and Search Summarization bring science-smart AI directly into your chemistry research workflow and reference searches. Multi-step questions get answered with cited, verifiable evidence in seconds.
Explore in CAS SciFinder →CAS Newton in CAS BioFinder
Agentic Search brings the same science-smart AI capability to your life sciences research workflow, orchestrating complex queries and returning directional answers grounded in verified biological sources.
Explore in CAS BioFinder →CAS Newton for CAS IP Finder™
Agentic search that transforms patent and IP searching with intuitive, conversational AI that understands your intent and delivers relevant insights.
Explore in CAS IP Finder →Experience CAS Newton in other tools
CAS Newton isn’t limited to CAS solutions. Through CAS Connections, the same science-smart agentic AI capability becomes available through ELNs, LIMs, discovery platforms, and other AI-driven environments your organization already uses. CAS Newton becomes a knowledge source to these tools through CAS Connections, making it possible to get cited, verifiable answers grounded in the CAS Content Collection within an existing workflow.
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For a structural biology–driven drug discovery lab like ours, CAS Newton becomes a sophisticated medicinal chemistry partner, enabling researchers without deep chemistry training to navigate complex design challenges with confidence. This capability can dramatically accelerate our efforts against diseases such as malaria and arboviral infections.
Glaucius Oliva
Professor Senior, Universidade de São Paulo
Interact conversationally in your native language
CAS Newton removes barriers to understanding and enables you to contextualize the direction of your thinking to take full advantage of 150 years of trusted scientific knowledge.
Trust and security
Protecting your ideas and data
CAS Newton operates within a secure CAS application boundary. No user input is shared outside the solution or in cross-user model training. Every output answer can be audited, providing your compliance and IP teams with the governance foundation they require. To understand how CAS approaches responsible and ethical AI, visit the CAS approach to ethical artificial intelligence.
CAS approach to ethical AI →No cross-user training
Your queries are never used to train AI models
Private Infrastructure
All data is maintained in a secure, private environment.
User confidentiality
Search activity never shared with other users or outside CAS
Full auditability
Every AI output traceable for compliance review
Evolving research requires better tools
Researchers are facing constant pressure to move from question to insight faster. CAS Newton is designed to help meet these challenges head-on, combining trusted science with more efficient workflows. Here are a few examples of ways CAS Newton can improve your research.
Uncovering Scientific Insights
Watch CAS Newton analyze chemical structures, biological relationships, and curated research data to answer complex scientific questions.
Optimizing Synthetic Routes
Identify opportunities for synthetic efficiency and scalability as CAS Newton analyzes reactions data and associated literature.
Unlocking IP Insights
Streamline your patent research with CAS Newton, uncovering insights and opportunities with an AI-enabled analysis of patent and scientific literature.
See CAS Newton in action
Your researchers deserve AI that understands their work. See what CAS Newton makes possible for your organization.