Journal publications

Decoding Reactions in Process Chemistry: A Quarter-Century Analysis of Trends and Transformations in OPR&D

This study provides the first comprehensive, data-driven analysis of process chemistry practices based on Organic Process Research & Development (OPR&D) publications from 2000–2025 indexed in the CAS Content Collection. More than 4,800 research articles encompassing over 34,000 reactions were analyzed to characterize commonly used synthetic methods, reagents, solvents, and reaction conditions in scalable processes. Industrial organizations contribute 65% of publications, underscoring the applied nature of the field. While cross-coupling—especially Suzuki coupling—dominates the literature, acylation and alkylation reactions are most frequently conducted in practice. Typical processes favor rapid, high-yield transformations (>90%) under ambient pressure with moderate heating (50–100 °C). Despite increasing regulatory scrutiny, THF and DCM remain the most prevalent solvents. Palladium-based catalysts and EDC for amide coupling continue to dominate, while flow chemistry has emerged as a key enabling technology. Overall, this analysis documents the evolution of process chemistry and provides evidence-based guidance for synthetic decision-making.

Org. Process Res. Dev. 2026, doi: 10.1021/acs.oprd.6c00001

CRISPR Technology: Transforming the Future of Medicine and Diagnostics.

CRISPR/Cas systems have emerged as a powerful platform for genome editing with wide-ranging implications for human disease. This article analyzes more than 53,000 journal and patent publications from the CAS Content Collection, spanning nearly three decades, to map the evolving landscape of CRISPR therapeutics and diagnostics. It identifies leading gene targets, delivery methods, and disease areas, examines organizational and commercial research activity, and surveys a clinical development pipeline of more than 140 CRISPR-based therapeutics, while also addressing the ethical dimensions of the technology.

Biochemistry 2025, 64 (24), 4628–4660. DOI: 10.1021/acs.biochem.5c00480

Rare Diseases, Spotlighting Amyotrophic Lateral Sclerosis, Huntington's Disease, and Myasthenia Gravis: Insights from Landscape Analysis of Current Research.

Rare diseases collectively affect a significant portion of the global population despite the individual rarity of each condition, with roughly 10,000 known rare diseases—80% of them genetic in origin. This review analyzes data from the CAS Content Collection to map the publication landscape, trace the evolution of key concepts, and examine genetic associations, emerging technologies, and treatment development pipelines across the rare disease space. Special focus is given to three specific conditions: amyotrophic lateral sclerosis, Huntington's disease, and myasthenia gravis.

Biochemistry 2025, 64 (8), 1698–1719. DOI: 10.1021/acs.biochem.4c00722

Assisted Reproductive Technology: A Ray of Hope for Infertility.

Assisted reproductive technologies (ART) have transformed reproductive medicine by expanding options for individuals and couples facing fertility challenges. This review draws on over 50,000 publications from the CAS Content Collection to analyze research trends in ART, covering established techniques such as in vitro fertilization and intracytoplasmic sperm injection alongside emerging approaches including in vitro gametogenesis, gene therapies, and AI integration. It identifies key substance classes, highlights the fastest-growing innovations, and addresses the ethical and regulatory considerations shaping the field's future.

ACS Omega 2025, 10 (22), 22347–22365. DOI: 10.1021/acsomega.5c01643

Leveraging Nanoscience for Advancing Heterogeneous Catalysis: An Analysis of the Influence of Nanocatalyst Dimensions.

Heterogeneous catalysis has been significantly advanced by nanoscience, with the high surface-to-volume ratio of nanomaterials enabling improvements in both reaction efficiency and selectivity. This review uses data from the CAS Content Collection to analyze publication trends in nanocatalyst research, examining how the dimensions and morphology of nanoscale catalysts—classified as 0D, 1D, 2D, and 3D—influence the reactions they catalyze, their applications, and their properties. It also explores geographic and organizational trends and highlights key directions in the field.

ACS Appl. Energy Mater. 2025, 8 (13), 8656–8679. DOI: 10.1021/acsaem.5c00315

Emerging Concepts in Immuno-Oncology: Insights from Natural Language Processing-Driven Co-Occurrence Analysis.

This article extends a prior CAS landscape analysis of immuno-oncology by examining how emerging concepts intersect across the literature. Using NLP-based co-occurrence analysis of more than 350,000 journal and patent publications from the CAS Content Collection, it identifies pairs of rapidly growing but still early-stage concepts across four groups—therapeutic targets, biomarkers, types of therapy, and types of cancer. The resulting relational analysis highlights promising intersections where the next breakthroughs in immuno-oncology research may emerge.

ACS Omega 2025, 10 (27), 28587–28614. DOI: 10.1021/acsomega.5c00693

Molecular Paleontology Meets Drug Discovery: The Case for De-extinct Antimicrobials.

The rise of antibiotic resistance has driven exploration of unconventional sources for novel antimicrobial agents, including the emerging field of molecular de-extinction — the reconstruction of bioactive peptides and antibiotics from ancient or extinct organisms. This article examines the convergence of paleogenomics, paleoproteomics, and synthetic biology, drawing on data from the CAS Content Collection to map the research landscape of de-extinct molecules. It reviews how advances in DNA sequencing, mass spectrometry, and computational biology are enabling the recovery and synthesis of antimicrobial agents from extinct species, and assesses the therapeutic potential and challenges of this approach.

ACS Omega 2025, 10 (37), 42175–42187. DOI: 10.1021/acsomega.5c05530

The Future of Epigenetics: Emerging Technologies and Clinical Applications.

Epigenetics — the study of heritable changes in gene expression without alterations to the underlying DNA sequence — has grown rapidly into a field of major clinical relevance. This review draws on over 120,000 epigenetic-related publications from the CAS Content Collection spanning 2000–2024 to examine the scientific foundations, key mechanisms, and technological innovations shaping the field. It traces publication trends across core epigenetic processes including DNA methylation, histone modification, and non-coding RNA regulation, and explores emerging therapeutic applications, clinical development pipelines, and the growing commercial interest in epigenetic targets.

ACS Pharmacol. Transl. Sci. 2026, 9 (3), 506–544. DOI: 10.1021/acsptsci.5c00729

Nanotechnology in Action: A Broad Perspective on Nanoscale Materials for Energy Applications.

‍This report analyzes trends in nanoscience research relevant to energy applications in an effort to provide a comprehensive and detailed picture of the use of nanotechnology in the field. It outlines the most discussed concepts and assesses the advantages of the various substances related to nanomaterials in the field of energy.

‍ACS Appl. Energy Mater, 2025. DOI: 10.1021/acsaem.5c00628

Nanoscience in Action: Unveiling Emerging Trends in Materials and Applications.

‍This article presents a large-scale analysis of over 3 million nanoscience documents using NLP and CAS indexing to identify 270+ emerging topics across materials, applications, and properties. Trendscape maps and data visualizations reveal growth patterns and interconnections, with a focus on four key application areas: drug delivery, sensors, energy, and catalysis. The findings aim to guide future research directions.

‍ACS Omega2025, 10 (8), 7530–7548. DOI: 10.1021/acsomega.4c10929

Transforming Medicine: Cutting-Edge Applications of Nanoscale Materials in Drug Delivery.

‍Nanotechnology has revolutionized drug delivery by enhancing bioavailability and reducing side effects. This article uses the CAS Content Collection to analyze trends in nanosized drug delivery systems, including their classes, delivery routes, and disease targets. It highlights key concepts and advantages of various nanocarriers, offering a broad overview of current knowledge, challenges, and opportunities in the field.

‍ACS Nano 2025, 19 (4), 4011–4038.DOI:10.1021/acsnano.4c09566

Nanoscale Materials in Biomedical Applications of Sensors: Insights from a Comprehensive Landscape Analysis.

‍Nanosensors, designed to detect and transmit signals at the nanoscale, are increasingly applied in biomedical contexts. This article analyzes trends using the CAS Content Collection, identifying leading nanomaterials—such as nanoparticles, nanotubes, and quantum dots—and highlighting chemical and biological sensors as dominant types. It explores emerging materials across substance classes and maps research and commercial interest, particularly in cancer diagnostics and drug discovery.

‍ACS Appl. Nano Mater. 2025, 8 (3), 1305–1331. DOI: 10.1021/acsanm.4c04463

Evolving Landscape of Parkinson’s Disease Research: Challenges and Perspectives

Parkinson’s disease (PD) is a progressive neurodegenerative disorder marked by dopamine neuron loss and motor dysfunction. This article analyzes research trends using the CAS Content Collection, highlighting advances in disease mechanisms, biomarkers, and therapeutic strategies. It explores genetic risk factors, pharmacological targets, comorbidities, and clinical development pipelines, offering insights into current challenges and future directions in PD research.

‍ACS Omega 2025, 10 (2), 1864–1892. DOI: 10.1021/acsomega.4c09114

Emerging Targets and Therapeutics in Immuno-Oncology: Insights from Landscape Analysis.

‍Immuno-oncology continues to reshape cancer treatment by targeting the immune system. This article analyzes over 350,000 journal and patent documents from the CAS Content Collection using natural language processing and CAS indexing to identify more than 300 emerging concepts. Organized into eight categories, these include therapeutic targets, biomarkers, and cancer types. The article highlights recent growth trends and offers insights to guide future research in this rapidly advancing field.

‍J. Med. Chem. 2024, 67 (11), 8519–8544. DOI: 10.1021/acs.jmedchem.4c00568

Unveiling Trends: Nanoscale Materials Shaping Emerging Biomedical Applications.

Biomedical materials research is rapidly advancing through interdisciplinary innovation. This article uses natural language processing and CAS Content Collection data to identify six emerging areas in nanoscale biomedical materials: self-healing, bioelectronic, programmable, lipid-based, protein-based, and antibacterial. It highlights how these materials enhance physical and electronic interfacing with tissues and enable advanced functions like programmable drug delivery.

‍ACS Nano 2024, 18 (26), 16325–16342. DOI: 10.1021/acsnano.4c04514

Navigating Antibacterial Frontiers: A Panoramic Exploration of Antibacterial Landscapes, Resistance Mechanisms, and Emerging Therapeutic Strategies.

‍The rise of antibiotic resistance has intensified the need for innovative antibacterial strategies. This review analyzes antibacterial research trends since 2012 using the CAS Content Collection, highlighting the evolution from traditional antibiotics to novel therapies. It explores resistance mechanisms and emphasizes the urgency of alternative approaches to address emerging bacterial threats and safeguard global health.

‍ACS Infect. Dis. 2024, 10 (5), 1483–1519. DOI: 10.1021/acsinfecdis.4c00115

Alzheimer’s Disease: Exploring the Landscape of Cognitive Decline

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by memory loss, cognitive decline, and functional impairment. This review analyzes research trends using the CAS Content Collection, highlighting advances in biomarkers, genetic risk factors, and pharmacological targets. It explores emerging concepts, comorbidities, and clinical development pipelines, offering insights into strategies for early diagnosis, treatment, and drug repurposing to combat AD.

‍ACS Chem. Neurosci. 2024, 15 (21), 3800–3827.DOI: 10.1021/acschemneuro.4c00339

Review of Carbon Nanotube Research and Development: Materials and Emerging Applications.

‍This review analyzes two decades of carbon nanotube (CNT) research using data from approximately 265,000 journal and patent publications. A natural language processing approach identifies over 80 emerging concepts across applications, materials, and properties. Key trends include a shift from synthesis methods like CVD to CNT composites with materials such as MXenes and MOFs. High-growth areas include energy storage, sensors, and wearable technologies, with increasing commercial interest across multiple industries.

‍ACS Appl. Nano Mater. 2024, 7 (16), 18695–18713. DOI: 10.1021/acsanm.4c02721

Biomarkers for Early Cancer Detection: A Landscape View of Recent Advancements, Spotlighting Pancreatic and Liver Cancers.

‍Early cancer detection significantly improves outcomes, and biomarkers play a key role in identifying malignancies at treatable stages. This review analyzes recent research trends using the CAS Content Collection and Excelra datasets, focusing on molecular and cellular biomarkers for early detection. It highlights development pipelines and evolving concepts, with special attention to pancreatic and liver cancers—two of the most challenging to detect early.

‍ACS Pharmacol. Transl. Sci. 2024, 7 (3), 586–613. DOI: 10.1021/acsptsci.3c00346

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.

Aging involves a gradual decline in physiological function and increased disease risk. This review uses the CAS Content Collection to examine global research trends in antiaging strategies, including lifestyle interventions, medical treatments, and emerging therapeutics. It highlights recent advances, development pipelines, and correlations with age-related diseases, offering a broad overview of current approaches and future opportunities in promoting healthy aging.

‍ACS Chem. Neurosci. 2024, 15 (3), 408–446. DOI: 10.1021/acschemneuro.3c00532

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement.

‍Aging is a progressive process marked by cellular damage and declining homeostasis, increasing vulnerability to disease. This review uses the CAS Content Collection to examine global research trends on aging mechanisms, highlighting key molecular and cellular hallmarks and their links to age-related diseases. It emphasizes brain aging, biochemical processes, and geographic patterns in research, offering insights into the evolving understanding of aging and its clinical implications.

‍ACS Chem. Neurosci. 2024, 15 (1), 1–30. DOI:10.1021/acschemneuro.3c00531

Three Decades of Single-Walled Carbon Nanotubes Research: Envisioning the Next Breakthrough Applications.

‍Since their discovery in 1993, single-walled carbon nanotubes (SWCNTs) have drawn significant attention for their exceptional mechanical, electronic, and optical properties. This perspective uses the CAS Content Collection to examine 30 years of SWCNT research, highlighting trends in synthesis, properties, and a wide range of applications—from energy and sensors to biomedicine and electronics. It emphasizes the growing potential of SWCNTs in next-generation integrated circuits and optoelectronics, and outlines future directions for realizing their transformative impact.

‍ACS Nano 2023, 17 (20), 19471–19473. DOI: 10.1021/acsnano.3c08909

The Evolving Landscape of Antibody–Drug Conjugates: In-Depth Analysis of Recent Research Progress.

‍Antibody–drug conjugates (ADCs) combine the precision of monoclonal antibodies with the potency of cytotoxic drugs, offering targeted cancer treatment with reduced systemic toxicity. This review analyzes recent trends in ADC research using the CAS Content Collection, highlighting advances in design, disease targets, and development pipelines. It also explores key technologies, company focus areas, and investment patterns, providing a comprehensive view of the field’s progress and future challenges.

‍Bioconjugate Chem. 2023, 34 (11), 1951–2000. DOI: 10.1021/acs.bioconjchem.3c00374

Messenger RNA-Based Therapeutics and Vaccines: What’s beyond COVID-19?

The success of mRNA vaccines against COVID-19 has propelled mRNA to the forefront of drug development. This review uses the CAS Content Collection to examine current trends in mRNA-based therapeutics and vaccines, including applications in infectious diseases, cancer, and immune disorders. It highlights key patents, delivery systems, and clinical trials, offering a broad view of the field’s progress and future potential in transforming modern medicine.

‍ACS Pharmacol. Transl. Sci. 2023, 6 (7), 943–969. DOI: 10.1021/acsptsci.3c00047

Sustainable Fertilizers: Publication Landscape on Wastes as Nutrient Sources, Wastewater Treatment Processes for Nutrient Recovery, Biorefineries, and Green Ammonia Synthesis.

‍Meeting global food demand sustainably requires innovation in fertilizer production. This review analyzes academic and patent literature from 2001 to 2021 using the CAS Content Collection, focusing on nutrient recovery from waste, wastewater treatment, biorefineries, and green ammonia synthesis. It highlights publication trends, regional contributions, and key materials, offering insights to support more efficient and eco-friendly fertilizer strategies.

‍J. Agric. Food Chem. 2023, 71 (22), 8265–8296. DOI: 10.1021/acs.jafc.3c00454

Trends in Research and Development for CO₂ Capture and Sequestration

Addressing the global challenge of climate change requires innovative strategies for carbon dioxide removal. This review presents a comprehensive analysis of CO₂ capture and sequestration technologies using data from the CAS Content Collection. It highlights recent advances in materials and processes for biological, chemical, and geological CO₂ mitigation, emphasizing scalable industrial applications. The review also explores the scientific and policy-driven efforts needed to achieve net-zero emissions by 2050, outlining current trends and persistent challenges in restoring environmental carbon balance.

‍ACS Omega 2023, 8 (13), 11643–11664. DOI: 10.1021/acsomega.2c05070

PEGylated Lipid Nanoparticle Formulations: Immunological Safety and Efficiency Perspective.

‍Lipid nanoparticles (LNPs), widely used in drug delivery and notably in mRNA COVID-19 vaccines, rely on PEG–lipid conjugates to enhance stability and pharmacokinetics. This review analyzes data from the CAS Content Collection to explore the dual role of PEGylation: improving systemic circulation while also triggering immune responses such as accelerated blood clearance (ABC) and complement activation-related pseudoallergy (CARPA). It examines how structural variations in PEG–lipids influence immunogenicity and delivery efficiency, offering insights to mitigate adverse effects and optimize therapeutic performance.

‍Bioconjugate Chem.2023,34 (6), 941–960. DOI: 10.1021/acs.bioconjchem.3c00174

Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders.

‍The gut microbiome–brain axis represents a dynamic, bidirectional communication system with profound implications for mental and gastrointestinal health. This review analyzes global research trends using the CAS Content Collection, highlighting the role of gut microbiota and their metabolites in regulating brain function and gut physiology. It explores the impact of dysbiosis on neurological and gastrointestinal disorders, the influence of the brain on microbial composition, and the clinical potential of microbiota-derived substances.

‍ACS Chem. Neurosci. 2023, 14 (10), 1717–1763. DOI: 10.1021/acschemneuro.3c00127

Trends and Opportunities in Organic Synthesis: Global State of Research Metrics and Advances in Precision, Efficiency, and Green Chemistry.

‍Organic synthesis continues to drive innovation across chemistry and related disciplines, with increasing focus on sustainability, precision, and societal benefit. This article presents a global analysis of organic synthesis research using the CAS Content Collection, identifying enzyme catalysis, photocatalysis, and green chemistry as key emerging areas. It highlights publication trends and advances aimed at improving synthetic efficiency, environmental responsibility, and the development of novel materials.

‍J. Org. Chem. 2023, 88 (7), 4031–4035. DOI: 10.1021/acs.joc.2c03057

Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics.

‍Exosomes are nanoscale extracellular vesicles with unique biological properties that make them promising tools for drug delivery and diagnostics. This article presents a global analysis of exosome research using the CAS Content Collection, highlighting trends in composition, cargo loading, therapeutic applications, and diagnostic potential. It explores their biogenesis, clinical development pipelines, and disease targets, emphasizing their growing role in precision medicine.

‍ACS Nano 2022, 16 (11), 17802–17846. DOI: 10.1021/acsnano.2c08774

Bioorthogonal Chemistry and Its Applications.

‍Bioorthogonal chemistry enables the study of biological processes using reactions that occur independently of native cellular chemistry. This article reviews key bioorthogonal reactions, their advantages, and their prevalence in the literature. Using the CAS Content Collection, it analyzes how these methods have been applied to proteins, carbohydrates, glycans, and lipids. Applications in imaging, biomolecule characterization, and drug delivery are highlighted, along with emerging uses and current limitations.

‍Bioconjugate Chem. 2021, 32 (12), 2457–2479. DOI: 10.1021/acs.bioconjchem.1c00461

Toward Predictive Chemical Deformulation Enabled by Deep Generative Neural Networks.

‍Reverse engineering chemical formulations is a complex challenge due to the vast number of potential ingredients. This article presents a deep learning approach using a variational autoencoder trained on a large, curated CAS dataset to predict ingredient quantities from known components. The model outperformed traditional methods, offering accurate deformulation across diverse product classes and demonstrating the potential of generative neural networks in industrial chemistry.

‍Ind. Eng. Chem. Res. 2021, 60 (39), 14176–14184. DOI: 10.1021/acs.iecr.1c00634

Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic.

‍Molecular glues have emerged as a promising class of small molecules in targeted protein degradation, offering a streamlined approach to recruiting E3 ligases for the ubiquitination and removal of disease-related proteins. This article analyzes recent research using the CAS Content Collection, highlighting the therapeutic potential of molecular glues in addressing traditionally “undruggable” targets. It reviews advances in drug discovery, outlines key degraders in development, and maps their progression through clinical pipelines.

‍Biochemistry 2023, 62 (3), 601–623. DOI: 10.1021/acs.biochem.2c00245

The Progress and Promise of RNA Medicine─An Arsenal of Targeted Treatments.

RNA-based therapeutics advanced rapidly over the past decade, driven by the success of mRNA vaccines and approved RNA drugs. This article provides a global analysis of RNA medicine using the CAS Content Collection, highlighting trends in RNA types, chemical modifications, delivery systems, and therapeutic pipelines. It emphasizes RNA’s dual role as both a drug and a target, underscoring its growing impact in modern medicine.

‍J. Med. Chem. 2022, 65 (10), 6975–7015. DOI: 10.1021/acs.jmedchem.2c00024

Materials Research Directions Toward a Green Hydrogen Economy: A Review.

Efforts to advance a hydrogen economy focused on materials innovations for hydrogen production, storage, and fuel cell utilization. This article reviews research from 2011 to 2021, highlighting trends in catalyst development for green hydrogen generation, storage technologies, and fuel cell materials. Analysis of publication data provides insights into key concepts and progress across each area of the hydrogen value chain.

‍ACS Omega 2022, 7 (37), 32908–32935. DOI: 10.1021/acsomega.2c03996

Intrinsically Disordered Proteins: Perspective on COVID-19 Infection and Drug Discovery.

‍The COVID-19 pandemic prompted investigation into novel therapeutic targets, including intrinsically disordered proteins (IDPs). This article examines the SARS-CoV-2 proteome for structural disorder, identifying key disordered regions in the nucleocapsid and select nonstructural proteins. Despite overall structural order, these IDPs play critical roles in viral function and virulence, making them promising targets for antiviral drug discovery.

‍ACS Infect. Dis. 2022, 8 (3), 422–432. DOI: 10.1021/acsinfecdis.2c00031

The Regulatory Environment for Lithium-Ion Battery Recycling.

‍As lithium-ion battery use expands, regulatory frameworks became increasingly important for managing environmental and material costs. This article reviews global LIB recycling regulations, focusing on the United States, European Union, and China. It examines how policy influences recycling economics, capacity development, and adoption of new technologies, emphasizing the need for regulation to realize the full societal and environmental benefits of LIB recycling.

‍ACS Energy Lett. 2022, 7 (2), 736–740. DOI: 10.1021/acsenergylett.1c02724

Lithium-Ion Battery Recycling─Overview of Techniques and Trends.

‍The rapid growth of lithium-ion battery use raised urgent concerns about resource scarcity and environmental impact. This article reviews recycling methods for LIBs, analyzing academic and patent literature from 2010 to 2021 using the CAS Content Collection. It compares hydrometallurgy, pyrometallurgy, and direct recycling techniques, and discussed economic and environmental challenges. A global overview of recycling facilities and capacities was also provided.

‍ACS Energy Lett. 2022, 7 (2), 712–719.DOI: 10.1021/acsenergylett.1c02602

Knowledge Graph-Based Approaches to Drug Repurposing for COVID-19.

‍The urgency of the COVID-19 pandemic accelerated efforts to repurpose existing drugs. This article describes the development of the CAS Biomedical Knowledge Graph, which identified 1350 small molecules targeting host proteins and disease processes relevant to COVID-19. A ranking algorithm prioritized candidates, with the top 50 including drugs already in clinical trials and novel compounds for further study. The approach demonstrates the potential of knowledge graphs to streamline drug discovery.

‍J. Chem. Inf. Model. 2021, 61 (8), 4058–4067. DOI: 10.1021/acs.jcim.1c00642

Artificial Intelligence in Chemistry: Current Trends and Future Directions.

‍The integration of artificial intelligence into chemistry research expanded rapidly over the past two decades. This article analyzes AI-related publications in the CAS Content Collection, revealing significant growth since 2015, particularly in analytical chemistry and biochemistry. It examines interdisciplinary trends, emerging research topics, and substance classes associated with AI applications, offering a broad overview of AI’s evolving role and future potential in chemical sciences.

‍J. Chem. Inf. Model. 2021, 61 (7), 3197–3212. DOI: 10.1021/acs.jcim.1c00619

Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement.

‍Lipid nanoparticles (LNPs) played a central role in the delivery of COVID-19 mRNA vaccines and emerged as versatile platforms for therapeutic delivery. This article reviews the evolution of LNP technologies, from early liposomes to advanced nanocarriers like solid lipid nanoparticles and nanostructured lipid carriers. Based on CAS Content Collection analysis, it highlights publication trends, therapeutic applications, and opportunities in fields such as oncology, vaccines, and beyond.

‍ACS Nano 2021, 15 (11), 16982–17015. DOI: 10.1021/acsnano.1c04996

A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development.

The global response to COVID-19 included an unprecedented surge in vaccine development. This article reviews a wide range of vaccine candidates and technologies, highlighting their respective advantages, limitations, and the use of adjuvants and delivery systems. It also examines both traditional and innovative approaches, offering insights into the scientific progress and future directions of vaccine research.

‍ACS Cent. Sci. 2021, 7 (4), 512–533. DOI: 10.1021/acscentsci.1c00120

Quantitative Structure–Activity Relationship Machine Learning Models and Their Applications for Identifying Viral 3CLpro- and RdRp-Targeting Compounds as Potential Therapeutics for COVID-19 and Related Viral Infections.

‍This article presents machine learning models developed to identify potential COVID-19 therapeutics targeting 3CLpro and RdRp. Using curated CAS data and bioassay results, the models screened FDA-approved drugs and antiviral-like compounds, revealing candidates with predicted activity, some supported by experimental data or clinical trials. The study highlights the role of AI in accelerating drug discovery for viral diseases.

‍ACS Omega 2020, 5 (42), 27344–27358. DOI: 10.1021/acsomega.0c03682

Potential Therapeutic Agents and Associated Bioassay Data for COVID-19 and Related Human Coronavirus Infections.

The search for COVID-19 treatments focused on identifying drug candidates targeting key viral and host proteins. This article reviews potential therapeutics supported by bioassay and structure–activity relationship data from literature and patents. It highlights small molecules and biologics acting on targets such as 3CLpro, PLpro, RdRp, and the S-protein–ACE2 interaction. The report supports drug repurposing and the discovery of new agents for treating coronavirus infections.

‍ACSPharmacol. Transl. Sci. 2020, 3 (5), 813–834. DOI: 10.1021/acsptsci.0c00074

Assay Techniques and Test Development for COVID-19 Diagnosis.

‍Accurate and accessible diagnostic testing was critical throughout the COVID-19 pandemic. This article reviewed assay techniques for detecting SARS-CoV-2 and related antibodies, focusing on molecular tests like RT-PCR and emerging methods such as isothermal amplification and CRISPR-based assays. It also covers serological tests including ELISA and lateral flow immunoassays. The report highlights innovations and outlines opportunities for advancing diagnostic technologies.

‍ACS Cent. Sci. 2020, 6 (5), 591–605. DOI: 10.1021/acscentsci.0c00501

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases.

‍The COVID-19 pandemic spurred a global scientific effort to develop effective treatments and vaccines. This article presents a CAS report analyzing published research and patents related to antiviral strategies targeting SARS-CoV-2 and related coronaviruses. It highlights small molecules, biologics, and repurposed drugs originally developed for other RNA viruses. The review also examines over 500 patents covering therapeutic antibodies, cytokines, nucleic acid-based therapies, and vaccine technologies.

ACS Cent. Sci. 2020, 6 (3), 315–331. DOI: 10.1021/acscentsci.0c00272

Recent Changes in the Scaffold Diversity of Organic Chemistry As Seen in the CAS Registry. Structural diversity in organic chemistry is evolving, shaped by both innovation and reuse. This study uses the CAS Registry to analyze trends in molecular frameworks—core ring systems and connecting chains—across a decade of compound data. It reveals that while frequently used scaffolds persist, new frameworks are steadily expanding chemical space. The review highlights shifts in scaffold usage, the influence of scientific and economic factors, and the growing role of rarely used structures. J. Org. Chem. 2019, 84 (21), 13948–13956. DOI: 10.1021/acs.joc.9b02111