As a specialist in scientific information solutions, CAS is partnering with research organizations around the globe to tackle the rapidly evolving and complex challenge of COVID-19. Aligned with our mission as a division of the American Chemical Society, CAS is making a wide range of resources and expertise openly available to support this fight. If customized support from CAS scientists and technologists would be valuable to augment your COVID-19 research efforts, we welcome your outreach to the CAS Customer Center.
Knowledge Graphs Accelerate COVID-19 Therapies
This whitepaper details the CAS Biomedical Knowledge Graph and shows how it was used in drug discovery for COVID-19.
Review of Global Efforts on COVID-19 Vaccine Development
This report reviews Covid-19 vaccine research, compares the underlying technologies, the use of adjuvants and delivery systems in their application, and provides a perspective on their future direction.
Covid-19 Vaccine Breakthroughs
This whitepaper explores the innovative research and technologies that played a crucial role in the development of Covid-19 vaccines.
QSAR Machine Learning Models and their Applications for Identifying Potential COVID-19 Therapeutics
To identify potential anti-SARS-CoV-2 therapeutics, CAS scientists are building machine-learning predictive models to identify novel drug candidates for the viral targets 3 chymotrypsin-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp).
Potential Therapeutics and Associated Bioassay Data for COVID-19
To support ongoing research and development of COVID-19 therapeutics, this report provides an overview of protein targets and corresponding potential drug candidates with bioassay and structure-activity relationship data found in the scientific and patent literature for COVID-19.
CAS COVID-19 Bioindicator Explorer
The CAS COVID-19 Bioindicator Explorer uses data extracted from our comprehensive journal and patent collection to identify correlations between drug-like substances with antiviral activity and COVID-19 protein targets.
CAS COVID-19 Antiviral Candidate SAR Dataset
This open source dataset contains over 290K structure-activity relationship (SAR) data directed at COVID-19 protein, virus and disease targets reported in the literature, patents, and other public sources for over 9K of the substances included in the CAS COVID-19 Antiviral Candidate Compounds Dataset.
Assay Techniques and Test Development for COVID-19 Diagnosis
To provide an understanding and comparison of the diagnostic tests available in the fight against COVID-19, this CAS report summarizes the basic principles of molecular and serological assays being used in diagnostic tests for SARS-CoV-2. The report highlights advancements in testing technologies and provides a look at currently available diagnostic tests.
CAS COVID-19 Protein Target Thesaurus
This collection of human-curated protein targets and their synonyms from CAS REGISTRY® and the CAS Thesaurus provides additional points of discovery to supplement your research.
CAS COVID-19 Antiviral Candidate Dataset
The open source dataset of nearly 50K chemical substances includes antiviral drugs and related compounds that are structurally similar to known antivirals for use in applications including research, data mining, machine learning, and analytics.
Open Access Article: R&D of Therapeutics and Vaccines of COVID-19 and related diseases
This CAS special report provides a comprehensive overview of published scientific information highlighting antiviral strategies involving small molecules and biologics targeting complex molecular interactions. Published in ACS Central Science.
Why the Omicron BA.5 Variant Evades Vaccines
As COVID-19 cases rise again worldwide, the Omicron subvariant BA.5 is currently the dominant strain. This blog explores some key mutations that …
COVID vaccine ingredients for children under 5
This blog lists and discusses the common ingredients (both in the household and scientific contexts) as well as the unique ingredients used in the …
Omicron variant accelerates need for more diverse COVID-19 vaccine strategy
Current vaccines against SARS-CoV-2 that target the spike protein are an important step toward developing antiviral therapeutics and next-generation …
COVID-19 vaccine boosters: what does the research show?
With recent mRNA booster recommendations, many ask if they should get a COVID-19 booster and what the science shows? This blog explains the science …
Exploring Knowledge Graphs for COVID-19 Drug Discovery
The methodology behind CAS knowledge graphs enhances potential drug identification for COVID-19 treatment and other diseases.
Coronavirus Variants: The Delta Variant and the Future Impact of Viral Mutations
If you are fully vaccinated, should you be worried about the impact of COVID-19 variants? Read this blog and learn about effectiveness of vaccines on …
Latest data on the safety and effectiveness of COVID-19 vaccines in children
Information covering CDC recommendation of pediatric COVID-19 vaccine for children ages 5-11, and original emergency use authorization from May 2021 …
Understanding the nanotechnology in COVID-19 vaccines
Lipid nanoparticles are a vital component of the Pfizer/BioNTech and Moderna mRNA COVID-19 vaccines, playing a key role in protecting and transporting …
Do other vaccines protect you from COVID-19?
Quickly after the emergence of COVID-19, it became clear that vaccines and drugs would be needed to tackle the SARS-CoV-2 virus and bring an end to …
Top 5 COVID-19 vaccine questions answered
CAS addresses some of the most common scientific questions about the current COVID vaccine candidates.
Meet the mRNA vaccine rookies aiming to take down COVID-19
mRNA vaccines have many potential advantages over conventional vaccines in mitigating the spread and eventually ending the COVID-19 pandemic. Learn …
Building on “flu shot” success to tackle COVID-19
Pharmaceutical companies and public health officials are leveraging experience with the well-known influenza vaccine to support successful …
Seeking COVID-19 Therapeutic Candidates with a Computational Approach
Learn how machine learning procedures and CAS COVID-19 resources, including scientific insights, open access datasets and special reports are …
Taking aim at COVID-19’s most wanted targets
In support of ongoing research efforts to identify additional drugs for COVID-19, a team of CAS scientists analyzed published scientific information …
Classic and new technologies vying to be the first COVID-19 vaccine
Storm warning – The critical role of cytokines in severe COVID-19
Serological tests indicate that inflammatory cytokine storm response is associated with COVID-19 severity and mortality. Understanding the biological …
Targeting ACE2 – Closing COVID-19’s cellular doorway
Since the outbreak of COVID-19, caused by SARS-CoV-2 virus, scientists have been racing to understand it. Extensive research has been devoted to …
The enemy within: How SARS-CoV-2 uses our own proteins to infect our cells
A critical step in the race to develop treatments for COVID-19 is to gain a clear understanding of how the virus enters our cells. This insight will …
Recent advances support scalability of COVID-19 diagnostic testing
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, continues to grip the world. Large-scale testing is required for countries to successfully …
Joining Forces to Accelerate COVID-19 Treatments
With millions of confirmed COVID-19 cases, and many more likely going untested, researchers around the world are racing to find solutions to this …
Beating COVID-19: Insights and strategies for new vaccines and therapies
The outbreak of COVID-19, caused by the new virus SARS-CoV-2, has spread rapidly across the world. Since the first report from Wuhan, China on …
Tracking COVID-19 Testing Technology - Infographic
This COVID-19 Testing Technology infographic summarizes both the key characteristics and benefits of the technologies needed, and the leading assay …