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Exosome CAS Insights article 3
Drug Discovery
Exosome research: from platelet dust to pioneering therapeutics
Landscape view of emerging contributors, companies, and researchers in the emerging field of exosome research. This article overviews key players in diagnostics and therapeutic fields of exosome...

Article

Targeting a Potentially Important Receptor in Disease Pathogenesis
Drug Discovery
ACE2: Targeting a Potentially Important Receptor in Disease Pathogenesis
Learn more about ACE2 the critical protein that remains the critical target of COVID-19 and so many additional viral infections. This overviews emerging trends and insights on publications,...

Article

Exosome hero article 2
Drug Discovery
Exosome therapy and diagnostics: the path to becoming clinical giants
Exosomes’ unique physical properties could unlock massive changes in the fields of drug delivery and diagnostics. However, the biggest challenge for exosomes is the methodologies of isolation and...

Article

cas-insights-nanoparticles
Drug Discovery
The therapeutic potential of nanotechnology beyond COVID-19
Learn more about lipid nanoparticles, their origin, role in COVID vaccines, and future applications. This overviews emerging trends and insights on publications, milestones, and future applications in...

Article

cytokines in severe COVID-19
Drug Discovery
Cytokine storm warning: The critical role of cytokines in immunity and infection
Learn more about cytokine storms and their role in both immunity and severe infection with COVID-19 and additional viral infections. This overviews emerging trends and insights on publications,...

Article

Drug Discovery
Breakthrough Therapy Designation: The Real-World Impact of Structural Novelty
Find out how companies improve their prediction accuracy, obtain Breakthrough Technology Status and shorten the development and review time of new drugs by leveraging CAS advanced machine learning...

Article

Neural network artificial intelligence
Drug Discovery
AI drug discovery: assessing the first AI-designed drug candidates to go into human clinical trials
This blog details the recently published CAS indicator of drug innovation based on the structural novelty of new molecular entities (NMEs) which may better assess innovativeness of new drugs.

Article

cover image for blog about RAS oncoprotein inhibitors in treating cancers
Drug Discovery
Emerging trends in targeting "undruggable" RAS proteins for cancer treatment
It is estimated that one in five human cancers involve RAS mutations. Although once considered undruggable, this blog looks at recent advances in RAS inhibitors and emerging therapies.

Article

picture of surgical mask
Drug Discovery
With COVID BA.5 and BA.2.75 Variants, Are Masks Back in?
The COVID pandemic revealed deficiencies in mask development and production. Innovation will be crucial in slowing the spread of new variants of the virus. There are many factors that can be improved...

Article

depiction of spike protein region on a Covid virus
Drug Discovery
Why the Omicron BA.5 Variant Evades Vaccines
As COVID-19 cases rise again worldwide, the Omicron subvariant BA.5 is currently the dominant strain. This blog explores some key mutations that increase transmission, evade protective antibodies, and...

Article

photo depicting a protein structure and folding
Drug Discovery
Are intrinsically disordered proteins the key to treating COVID-19?
Learn about the important functions of intrinsically disordered proteins and the key role they play in COVID-19 therapy.

Article

photo of child being vaccinated
Drug Discovery
COVID vaccine ingredients for children under 5
This blog lists and discusses the common ingredients (both in the household and scientific contexts) as well as the unique ingredients used in the Covid-19 vaccines currently in use in the United...

Article

COVID Omicron variant illustration
Drug Discovery
Omicron variant accelerates need for more diverse COVID-19 vaccine strategy
Preliminary study of the Omicron variant indicates that it has evolved significantly from the original version of the virus first identified in China in 2019, which means there is an increased...

Article

CAS Biomedical Knowledge Graph thumbnail image
Drug Discovery
Exploring Knowledge Graphs for COVID-19 Drug Discovery
The methodology behind CAS knowledge graphs enhances potential drug identification for COVID-19 treatment and other diseases.

Article

Drug Discovery
Seeking COVID-19 Therapeutic Candidates with a Computational Approach
Learn how machine learning procedures and CAS COVID-19 resources, including scientific insights, open access datasets and special reports are assisting in the research to fight against COVID-19.

Article

Drug Discovery
Taking aim at COVID-19’s most wanted targets
In support of ongoing research efforts to identify additional drugs for COVID-19, a team of CAS scientists analyzed published scientific information and created a comprehensive report focusing on...

Article

Viral spike-protein structure depiction
Drug Discovery
The enemy within: How SARS-CoV-2 uses our own proteins to infect our cells
A critical step in the race to develop treatments for COVID-19 is to gain a clear understanding of how the virus enters our cells. This insight will support development of targeted anitviral...

Article

RNA-HERO-1920x1080
Biotechnology
RNA medicines: what technologies are investors funding?
Learn about market trends in the RNA medicine space and what technological approaches and indications investors are backing.

Article

Breakthroughs-1920x1080
Emerging Science
Top scientific breakthroughs and emerging trends for 2023
Stay ahead of the curve with the latest in emerging science and cutting-edge research that is accelerating the landscape of innovation. From new discoveries in synthetic biology to breakthroughs in...

Article

the evolving exosome hero
Biotechnology
The evolving exosome: from small player to rising star
A historical overview of the discovery of exosomes, key milestones in their rise, and why they will revolutionize the diagnostic and drug delivery fields in the future.

Article

Photo of Nobel Prize medal
Emerging Science
Key Insights on Click Chemistry and Bioorthogonal Chemistry
Learn about the basics of click chemistry and bioorthogonal chemistry that was recently awarded the 2022 Nobel Prize in Chemistry. Read about emerging trends, insights on publication trends, and...

Article

Digital R&D
The rise of AI drug development technology
"When you’re finished changing, you’re finished." Business leaders likely weren't the intended audience when Benjamin Franklin uttered his now famous quote. However, his words likely resonate...

Article

Biotechnology
The long road to success: Refining the next generation of mRNA vaccines
mRNA vaccines have many potential advantages over conventional vaccines in mitigating the spread and eventually ending the COVID-19 pandemic. Learn more about mRNA vaccines and how CAS is committed to...

Article

RNA Medicines blog thumbnail
Biotechnology
Molecular glues and induced proximity: solving the undruggable
Molecular glues have been used to uncover new therapeutic agents. Because of their targeted protein degradation that holds them together, these glues have exciting potential in uncovering new drugs to...

Article

Monkeypox virus cellular depiction
Emerging Science
Monkeypox: scientifically, how worried should we be?
With recent headlines on monkeypox, learn more about the research landscape, scientific profiles, and currently available therapies. A deeper understanding of the published science enables clarity...

Article

photo showing sample vials of RNA based therapeutics
Biotechnology
A therapeutic revolution: RNA in COVID-19 and beyond
We are in the midst of a therapeutic revolution, according to the authors of a recent review article in Frontiers in Bioengineering and Biotechnology. They were commenting on the rapid expansion of...

Article

picture of brain
Emerging Science
How Your Gut Microbiome is Linked to Depression and Anxiety
Gut microbiota, gut flora, or microbiome are the microorganisms that live in the digestive tracts of humans and other animals. While some bacteria are associated with disease, others are particularly...

Article

Nurse administering booster vaccine
Biotechnology
COVID-19 vaccine boosters: what does the research show?
With recent mRNA booster recommendations, many ask if they should get a COVID-19 booster and what the science shows? This blog explains the science of boosters, reviews current recommendations, and...

Article

Use of lipid nanoparticles in cancer therapy
Biotechnology
Lipid Nanoparticles – Key Players in Cancer Treatment
Lipid nanoparticles are key therapeutic vehicles in the pharmaceutical industry, as well as medical imaging, cosmetics, nutrition and more. Discover how lipid nanoparticles are applied in cancer...

Article

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