CAS Science Team

Why are there no FDA approved TBK1 (TANK-binding kinase) inhibitors on the market, despite the key role it plays in the pathophysiology of many diseases.

Biomedicine, batteries, and more could be revolutionized by carbon nanotubes. See the full range of their applications.

Este detallado informe técnico, publicado en colaboración con la Universidad de Westlake, analiza el panorama de los biomateriales y cómo este campo está cambiando rápidamente.

Learn about the shift towards sustainable and natural ingredients in cosmetics, supported by data from the CAS Content Collection™.

Different types of antisense oligonucleotide therapies, such as exosomes and nanoparticles, offering new hope in genetic medicine.

Unlock the potential of nanotechnology. Explore breakthroughs and challenges in energy, biomedicine, and more in our executive summary.

This biomaterials Insights Report explores eight key areas transforming healthcare with self-healing implants, targeted drug delivery, and more.

Descubra la ciencia detrás de los edulcorantes, sus impactos en la salud, las tendencias de investigación y desarrollo y los datos de inversión.

Carbon nanotubes (CNTs) hold immense promise for batteries, composites, sensors, and more. Discover emerging trends on overcoming challenges and cutting edge applications.

Biomarkers could help doctors catch cancer earlier, cure it more frequently, and perform treatments with fewer risks.

Recycling semiconductors was once a far-off dream. However, new research and technology shows that this could become reality.

See key insights on emerging RNA IP trends and possibilities for future innovations in this executive summary.

As antimicrobial resistance becomes a larger problem, new approaches to battling infections are emerging.

The landscape of exosomes has become highly competitive. See all the recent investments, innovations, and commercial opportunities.

Discover how AI in the food industry is transforming production, innovation, and sustainability. Learn how AI can help you create smarter and more efficient food solutions.

Immunotherapy is advancing with new approaches like CAR-T cell therapy, antibody-drug conjugates, and even checkpoint inhibitors.

Stay ahead of the latest scientific breakthroughs that are accelerating the landscape of innovation and will transform global science in 2024

The pharma industry is tackling major drug discovery challenges in several new ways. Have they been successful?

With the push towards increased sustainability, here are four ways coatings manufacturers are making use of renewable feedstock for their own products.

Covalent inhibitors were once avoided due to negative side effects, but new drugs have changed the landscape.

Drugs created with covalent inhibitors are becoming more popular than other types, owing to their unique mechanism of action.

More than 100 antibody-drug conjugates are in clinical trials. These therapeutics combine the targeting abilities of antibodies with the power of chemotherapy to change cancer treatment.

Incomplete prior art searches and analyses can lead to costly mistakes, leaving innovations and the value of intellectual property open to huge risk.

CAS scientists discuss overlooked ideas that have yet to win a Nobel Prize. From OLEDs and MOFs to mRNA therapeutics and more, these ideas have reshaped science and technology.

Patentability assessments in scientific industries come with significant challenges due to their complexity. However, CAS has tools designed to address these issues.

CAS, the LaJolla Institute for Immunology, and Avidity Biosciences explore the convergence of biology and chemistry in emerging therapeutics for cancer, vaccines, and more.

With consumers changing their diets for personal and health reasons, innovation to increase quality and variety creates a diverse and competitive market.

Hero ingredients can help create more advanced and versatile formulations than ever before as consumers slim down their cosmetic routines.

Chemistry is powering space exploration with rocket fuel and engine technologies. Discover the advantages and challenges of using LOX/LH2 as a propellant for the Artemis mission.

Catalysts have been enabling green chemistry with applications in many industries.

Thanks to mRNA vaccines, which have revolutionized the fight against COVID-19, we can treat cancer by harnessing the power of the immune system.

Biomaterials like hydrogels, lipid nanoparticles, and exosomes are reshaping the landscape of drug delivery, diagnosis, and therapeutics.

Learn how leveraging patent tools and strategies can accelerate your path toward comprehensive searches and stronger insights.

Research in anti-aging treatments has reached a pivotal point. How do new treatments, drugs, and clinical trials compare to time-tested practices?

Accelerate and improve the ROI of your IP and R&D initiatives by partnering with an industry and IP expert.

Microplastics have infiltrated our entire world, even down to the water we drink and food we eat. Researchers are looking at new ways to address them.

A successful patent landscape analysis can maximize opportunities and de-risk your company's R&D program and other initiatives.

Induced-proximity target protein degradation (TPD) is a ground-breaking strategy in drug discovery that has emerged recently.

Graphene-based supercapacitor technologies are being levied for real-world applications as a battery alternative.

What is dark data, and how can it be used to unlock data insights and accelerate innovation for R&D?

mRNA vaccines created for COVID-19 have led to a slew of new research in mRNA therapeutics.

Discover how advances in 3D printing materials and approaches have reshaped tissues and organ sourcing, drug delivery methods, and wound care.

Investment in RNA has grown beyond vaccines. Cancer, infectious diseases, and even liver diseases have all been identified for RNA medicines.

Learn five ways to reduce waste and use biodegradable materials to develop sustainable sterile packaging options for medical devices.

PEG immunogenicity is a challenge that affects the safety and efficacy of PEGylated lipid nanoparticles for drug delivery.

Learn how PEGylated lipid nanoparticles are used to deliver mRNA vaccines and other drugs, the immunogenicity concerns with vaccines, and emerging approaches on new designs to increase efficacy and safety.

This publication in the ACS Chemical Neuroscience Journal details a landscape analysis of emerging trends in the gut microbiome space.

Created in collaboration with Bayer AG, this report discusses the latest research on microbiome-based therapies, microbiota, probiotics, and the wide range of health conditions it can influence.

Microplastic pollution is a global problem due to their disruption of ecosystems and their ingestion by humans and animals.

Exosomes are reshaping the future of drug delivery, therapeutics, and diagnostics. Learn about exosomes and the challenges with the technology.

3D printing has major biomedical applications. See the new technologies that are reshaping personalized healthcare.

This article, published in collaboration with the National Natural Science Foundation of China, the Chinese Academy of Sciences, and CAS, examines the state of global synthetic organic chemistry research with a focus on enzyme catalysis, photocatalysis, and green chemistry.

CAS and the Chinese Academy of Sciences explore hidden connections and publication trends in synthetic organic chemistry.

Agriculture and fertilizers have a sustainability problem. Understand emerging trends around reducing this industry's carbon emissions.

Incidents like the East Palestine chemical spill have led researchers to reevaluating the safety of transporting hazardous materials.

The expansion of exosome research has led to significant clinical advancements, and new approaches to drug delivery and diagnostics.

From prosthetic ears to artificial organs, learn about the latest trends and innovations in 3D printing in biomedicine.

The possibilities of 3D printing in biomedicine are nearly limitless, as evidenced by this journal publication.

Explore the path to sustainable agriculture and learn about the key role it plays in global food production. Discover how reducing, reusing, and recycling can improve fertilizer access, minimize environmental impact and dependence on finite resources, and lead to a circular bioeconomy. Learn about the latest innovations in sustainable agriculture, including smart nano-fertilizers, biorefineries, and biochar, and see how they can be used to harness the nutrient content of waste products to bolster food production and protect the environment.

Hydrogen fuel technology is being examined for powering electricity, heating, and transportation.

We analyze the scientific and patent trends on sustainable fertilizers in the CAS Content Collection to help scientists use new, more environmentally friendly sources.

Synthetic fertilizers ae valuable but leave a large carbon footprint. Sustainable fertilizers are an environmentally friendly alternative that is growing in interest.

Methods to push back against the wave of microplastics that are poisoning the environment are in full swing.

Microplastics come from countless sources and have a large impact on the environment. Scientists are working hard to combat this growing problem.

The FDA can designate drug candidates as “breakthrough therapies” (breakthrough therapy designation or BTD) for certain drug candidates that demonstrate substantial improvement over available therapies on a clinically significant endpoint.

Exosomes – nature's lipid nanoparticle, a rising star in drug delivery and diagnostics

Exosomes are nature’s lipid nanoparticles and their unique physical properties will unlock new applications in drug development, delivery and diagnostic applications in the future

Bioorthogonal chemistry is a set of methods that use the chemistry of non-native functional groups to analyze biology in living organisms.

Learn about the basics of click chemistry and bioorthogonal chemistry that was recently awarded the 2022 Nobel Prize in Chemistry. Read about emerging trends, insights on publication trends, and future applications of bioorthogonal chemistry.

Timeline showing key reactions and applications culminating in 2022 Nobel Prize in Chemistry

When mRNA (messenger RNA) vaccines are injected into a patient, tiny lipid vesicles transport mRNA molecules through the body fluids and merge with immune cells, called antigen-presenting cells (APCs).

Scientists are searching ways to stop the spread of COVID-19, and the ACE2 receptor is one of the most promising targets.

With over 90% of the world’s plastics production requiring fossil fuels, bio-based polymers generated from renewable sources have substantial benefits over traditional plastics – from reducing CO2 emissions, increased biodegradability, and less dependence on fossil fuels. Learn more in our landscape

Learn more about the scientific challenges, emerging technologies, and the financial and environmental implications for recycling lithium ion batteries.

Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms.

This whitepaper explores challenges and opportunities for worldwide patent offices as they seek to ensure sustainability and future growth. It focuses on the application of artificial intelligence-enabled workflow solutions to enhance productivity and patent quality.

Scientists at Bayer expand their understanding into new, useful chemistry by improving the predictive power of a synthesis planning model with scientist-curated reactions from CAS.

This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.

This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.

Targeted protein degradation is a novel and quickly expanding drug discovery strategy. It is a new way of utilizing disease-causing proteins to attack severe illnesses, which has the potential to be used among more serious illnesses, such as cancer or neurodegenerative diseases.

Artificial intelligence (AI) and machine learning have been growing exponentially over the last decade, but how has the field of Chemistry evolved with this emerging trend?

The use of RNA in therapeutics has the potential to revolutionize medicine. This white paper highlights the emerging trends in the industry.

Lipid nanoparticles play critical roles in mRNA vaccines for treating COVID-19, but their use is not new. Read about past, present, and future opportunities.

The last decade has seen a dramatic shift towards RNA-based medicine. Rapid success in developing lipid-RNA nanoparticles for COVID-19 mRNA vaccines, along with several approved drugs, has propelled RNA to the forefront of pharmaceutical research and development. Explore this revolutionary trend.

Many technologies have been researched with an eye toward enabling a hydrogen economy.

Most synthetic polymers are derived from fossil fuel resources, whose scarcity and imbalanced global distribution can affect plastics producers. Bio-based polymers, obtained from renewable biomass resources, have received wide attention in the past two decades.

This white paper details the CAS Biomedical Knowledge Graph and shows how it was used in drug discovery for COVID-19.

While human capabilities have only increased due to recent technological and medical advances, they have significantly contributed to the release of around 830 gigatons of CO2 into the atmosphere in just the last 30 years alone.

It turns out that these intrinsically disordered proteins may be the key to better overcoming diseases in neurodegeneration, diabetes, cardiovascular disease, amyloidosis, genetic diseases, and cancer.

Learn more about carbon capture, storage, and reduction in our landscape view of this emerging research with unique insights.

Lithium-ion batteries (LIBs) are commonly used in a variety of consumer products, including cellular phones, laptop computers, and more recently, electric and hybrid vehicles.

As the production and usage of lithium-ion batteries (LIBs) has increased exponentially, their manufacturing and disposal have become subjects of political and environmental concerns.

The COVID-19 pandemic has motivated researchers across the globe to find effective drugs and therapeutics for treating the disease.

En los últimos años, la aplicación de la IA a la química ha crecido rápidamente. Si bien ha habido mucha publicidad sobre la IA utilizada de esta manera, no ha habido muchos análisis en profundidad sobre su uso y desarrollo en el campo de la química.

Lipid nanoparticles (LNPs) have emerged as promising vehicles to deliver a variety of therapeutics in the pharmaceutical industry. Liposomal drugs, based on an earlier version of LNPs, have already been approved and applied to medical practice.

This report reviews Covid-19 vaccine research, compares the underlying technologies, the use of adjuvants and delivery systems in their application, and provides a perspective on their future direction.

This in-depth CAS Insights Report discusses the chemical properties of ammonium nitrate, its hazards and safety rules, and provides a useful resource for those involved in the handling and storage of this compound.

Artificial Intelligence may be hot right now, but the smart money is investing in data. See how CAS solutions can help.

To identify potential anti-SARS-CoV-2 therapeutics, CAS scientists are building machine-learning predictive models to identify novel drug candidates for the viral targets 3 chymotrypsin-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp).

This report aids COVID-19 therapeutic research by summarizing protein targets and potential drug candidates. It includes bioassay and structure-activity relationship data from scientific and patent literature for COVID-19 and related viral infections. Explore key insights to support ongoing drug dev