CAS Science Team

Bio

Digital R&D

Defining the path to TBK1 inhibition with QSAR modeling

Why are there no FDA approved TBK1 (TANK-binding kinase) inhibitors on the market, despite the key role it plays in the pathophysiology of many diseases.
|Insights Report
Materials

Idea in brief: Emerging trends and future opportunities for carbon nanotubes

Biomedicine, batteries, and more could be revolutionized by carbon nanotubes. See the full range of their applications.
|Executive Summary
Materials

Publicación del CAS y la Universidad de Westlake sobre biomateriales: informe completo

Este detallado informe técnico, publicado en colaboración con la Universidad de Westlake, analiza el panorama de los biomateriales y cómo este campo está cambiando rápidamente.
|Insights Report
Consumer Goods

Evolving beauty: The rise of sustainable and natural ingredients for cosmetics

Learn about the shift towards sustainable and natural ingredients in cosmetics, supported by data from the CAS Content Collection™.
|Article
Drug Discovery

Types of antisense oligonucleotides: Advancing therapeutic frontiers

Different types of antisense oligonucleotide therapies, such as exosomes and nanoparticles, offering new hope in genetic medicine.
|Article
Materials

How nanotechnology delivers massive change in energy, biomedicine and more.

Unlock the potential of nanotechnology. Explore breakthroughs and challenges in energy, biomedicine, and more in our executive summary.
|Insights Report
Materials

The material difference: How biomaterials are reshaping medicine and patient outcomes

This biomaterials Insights Report explores eight key areas transforming healthcare with self-healing implants, targeted drug delivery, and more.
|Insights Report
Consumer Goods

Desentrañando la ciencia detrás de los edulcorantes artificiales

Descubra la ciencia detrás de los edulcorantes, sus impactos en la salud, las tendencias de investigación y desarrollo y los datos de inversión.
|Executive Summary
Materials

From batteries to drug delivery: Emerging applications of carbon nanotubes

Carbon nanotubes (CNTs) hold immense promise for batteries, composites, sensors, and more. Discover emerging trends on overcoming challenges and cutting edge applications.
|Article
Emerging Science

16 billion reasons for hope: How biomarkers are reshaping cancer outcomes

Biomarkers could help doctors catch cancer earlier, cure it more frequently, and perform treatments with fewer risks.
|Executive Summary
Sustainability

Science fact vs. fiction: Can we recycle semiconductors?

Recycling semiconductors was once a far-off dream. However, new research and technology shows that this could become reality.
|Article
Intellectual Property

IP trends and opportunities: RNA therapeutics

See key insights on emerging RNA IP trends and possibilities for future innovations in this executive summary.
|Executive Summary
Emerging Science

Idea in brief: battling antibiotic resistant infections

As antimicrobial resistance becomes a larger problem, new approaches to battling infections are emerging.
|Executive Summary
Intellectual Property

Keeping a finger on the pulse of exosome IP and innovation

The landscape of exosomes has become highly competitive. See all the recent investments, innovations, and commercial opportunities.
|Executive Summary
Digital R&D

Embracing the future of AI in the food industry

Discover how AI in the food industry is transforming production, innovation, and sustainability. Learn how AI can help you create smarter and more efficient food solutions.
|Article
Drug Discovery

R&D Insight: Unique views into immuno-oncology

Immunotherapy is advancing with new approaches like CAR-T cell therapy, antibody-drug conjugates, and even checkpoint inhibitors.
|Executive Summary
Emerging Science

Scientific breakthroughs: 2024 emerging trends to watch

Stay ahead of the latest scientific breakthroughs that are accelerating the landscape of innovation and will transform global science in 2024
|Article
Drug Discovery

Dealing with the challenges of drug discovery

The pharma industry is tackling major drug discovery challenges in several new ways. Have they been successful?
|Article
Sustainability

Four uses for renewable feedstock in sustainable coatings

With the push towards increased sustainability, here are four ways coatings manufacturers are making use of renewable feedstock for their own products.
|Article
Drug Discovery

R&D insights: The covalent inhibitor revolution

Covalent inhibitors were once avoided due to negative side effects, but new drugs have changed the landscape.
|Executive Summary
Biotechnology

The rise of covalent inhibitors in strategic therapeutic design

Drugs created with covalent inhibitors are becoming more popular than other types, owing to their unique mechanism of action.
|Article
Drug Discovery

R&D insights: Antibody-drug conjugates

More than 100 antibody-drug conjugates are in clinical trials. These therapeutics combine the targeting abilities of antibodies with the power of chemotherapy to change cancer treatment.
|Executive Summary
Intellectual Property

Prior art search and analysis for scientific IP strategies

Incomplete prior art searches and analyses can lead to costly mistakes, leaving innovations and the value of intellectual property open to huge risk.
|Article
Emerging Science

Quantum dots win the 2023 Nobel Prize for Chemistry

CAS scientists discuss overlooked ideas that have yet to win a Nobel Prize. From OLEDs and MOFs to mRNA therapeutics and more, these ideas have reshaped science and technology.
|Article
Intellectual Property

Navigating patentability assessments in scientific industries

Patentability assessments in scientific industries come with significant challenges due to their complexity. However, CAS has tools designed to address these issues.
|Article
Emerging Science

CAS Symposium Explores Convergence of Biology and Chemistry in Emerging Therapeutics

CAS, the LaJolla Institute for Immunology, and Avidity Biosciences explore the convergence of biology and chemistry in emerging therapeutics for cancer, vaccines, and more.
|Article
Sustainability

Going green with plant-based meat sustainability

With consumers changing their diets for personal and health reasons, innovation to increase quality and variety creates a diverse and competitive market.
|Article
Consumer Goods

Multifunctional cosmetics: Developing a product that ‘does it all’

Hero ingredients can help create more advanced and versatile formulations than ever before as consumers slim down their cosmetic routines.
|Article
Emerging Science

Mars is calling, but how will Artemis fuel the journey?

Chemistry is powering space exploration with rocket fuel and engine technologies. Discover the advantages and challenges of using LOX/LH2 as a propellant for the Artemis mission.
|Article
Sustainability

R&D insights: Sustainable catalysts for the future

Catalysts have been enabling green chemistry with applications in many industries.
|Executive Summary
Biotechnology

From fighting viruses to tackling tumors: Harnessing mRNA vaccines to treat cancer

Thanks to mRNA vaccines, which have revolutionized the fight against COVID-19, we can treat cancer by harnessing the power of the immune system.
|Article
Emerging Science

Top 10 emerging trends in biomaterials

Biomaterials like hydrogels, lipid nanoparticles, and exosomes are reshaping the landscape of drug delivery, diagnosis, and therapeutics.
|Insights Report
Intellectual Property

Patent searching: Going beyond the basics to increase efficiency

Learn how leveraging patent tools and strategies can accelerate your path toward comprehensive searches and stronger insights.
|Article
Emerging Science

Executive summary: What’s next in anti-aging treatments?

Research in anti-aging treatments has reached a pivotal point. How do new treatments, drugs, and clinical trials compare to time-tested practices?
|Executive Summary
Intellectual Property

The why’s and how’s of partnerships in scientific patent searching

Accelerate and improve the ROI of your IP and R&D initiatives by partnering with an industry and IP expert.
|Article
Sustainability

Infographic: What can be done about microplastics?

Microplastics have infiltrated our entire world, even down to the water we drink and food we eat. Researchers are looking at new ways to address them.
|Infographic
Intellectual Property

Maximize opportunities with a patent landscape analysis

A successful patent landscape analysis can maximize opportunities and de-risk your company's R&D program and other initiatives.
|Article
Drug Discovery

Targeted protein degradation and induced proximity: Molecular glues landscape in drug discovery

Induced-proximity target protein degradation (TPD) is a ground-breaking strategy in drug discovery that has emerged recently.
|Insights Report
Sustainability

Supercapacitor technologies: Is graphene finally living up to its full potential?

Graphene-based supercapacitor technologies are being levied for real-world applications as a battery alternative.
|Article
Digital R&D

Unlocking the power of dark data in chemistry R&D: Strategies for success

What is dark data, and how can it be used to unlock data insights and accelerate innovation for R&D?
|Article
Emerging Science

Top emerging trends in mRNA therapeutics

mRNA vaccines created for COVID-19 have led to a slew of new research in mRNA therapeutics.
|Executive Summary
Biotechnology

Infographic: 3D printing is reshaping the future of biomedicine

Discover how advances in 3D printing materials and approaches have reshaped tissues and organ sourcing, drug delivery methods, and wound care.
|Infographic
Biotechnology

Infographic: Top investment trends for RNA and the outlook ahead

Investment in RNA has grown beyond vaccines. Cancer, infectious diseases, and even liver diseases have all been identified for RNA medicines.
|Infographic
Sustainability

Five ways to achieve sustainable medical packaging

Learn five ways to reduce waste and use biodegradable materials to develop sustainable sterile packaging options for medical devices.
|Article
Emerging Science

What you need to know about PEG immunogenicity

PEG immunogenicity is a challenge that affects the safety and efficacy of PEGylated lipid nanoparticles for drug delivery.
|Executive Summary
Emerging Science

Peer-reviewed journal: PEG immunogenicity and vaccine safety

Learn how PEGylated lipid nanoparticles are used to deliver mRNA vaccines and other drugs, the immunogenicity concerns with vaccines, and emerging approaches on new designs to increase efficacy and safety.
|Journal Publication
Emerging Science

Peer reviewed publication: New discoveries on emerging microbiome trends

This publication in the ACS Chemical Neuroscience Journal details a landscape analysis of emerging trends in the gut microbiome space.
|Journal Publication
Emerging Science

Recognizing the potential of the gut microbiome

Created in collaboration with Bayer AG, this report discusses the latest research on microbiome-based therapies, microbiota, probiotics, and the wide range of health conditions it can influence.
|Insights Report
Sustainability

R&D Insights: Tiny microplastics with massive implications

Microplastic pollution is a global problem due to their disruption of ecosystems and their ingestion by humans and animals.
|Executive Summary
Biotechnology

Exosomes, the rising star of therapeutics: Infographic

Exosomes are reshaping the future of drug delivery, therapeutics, and diagnostics. Learn about exosomes and the challenges with the technology.
|Infographic
Biotechnology

R&D Insights: 3D printing in biomedical applications

3D printing has major biomedical applications. See the new technologies that are reshaping personalized healthcare.
|Executive Summary
Synthetic Chemistry

Synthetic organic chemistry: Peer-reviewed landscape publication

This article, published in collaboration with the National Natural Science Foundation of China, the Chinese Academy of Sciences, and CAS, examines the state of global synthetic organic chemistry research with a focus on enzyme catalysis, photocatalysis, and green chemistry.
|Journal Publication
Synthetic Chemistry

Top emerging trends in synthetic organic chemistry

CAS and the Chinese Academy of Sciences explore hidden connections and publication trends in synthetic organic chemistry.
|Insights Report
Sustainability

R&D Insights: Sustainable agriculture and fertilizer production

Agriculture and fertilizers have a sustainability problem. Understand emerging trends around reducing this industry's carbon emissions.
|Executive Summary
Safety

The science behind dioxins, vinyl chloride, and proven remediations

Incidents like the East Palestine chemical spill have led researchers to reevaluating the safety of transporting hazardous materials.
|Article
Biotechnology

R&D Insights: Exosomes in drug delivery and diagnostics

The expansion of exosome research has led to significant clinical advancements, and new approaches to drug delivery and diagnostics.
|Executive Summary
Biotechnology

From polymers to prosthetics: the growth of 3D printing in biomedicine

From prosthetic ears to artificial organs, learn about the latest trends and innovations in 3D printing in biomedicine.
|Insights Report
Biotechnology

Explore biomedicine’s 3D printing scientific journal review

The possibilities of 3D printing in biomedicine are nearly limitless, as evidenced by this journal publication.
|Journal Publication
Sustainability

Hydrogen fuel-Insights into a growing market

Hydrogen fuel technology is being examined for powering electricity, heating, and transportation.
|Insights Report
Sustainability

Scientific review on sustainable fertilizers

We analyze the scientific and patent trends on sustainable fertilizers in the CAS Content Collection to help scientists use new, more environmentally friendly sources.
|Journal Publication
Sustainability

Innovation in sustainable fertilizer production

Synthetic fertilizers ae valuable but leave a large carbon footprint. Sustainable fertilizers are an environmentally friendly alternative that is growing in interest.
|Insights Report
Sustainability

Scientific review on microplastics pollution

Methods to push back against the wave of microplastics that are poisoning the environment are in full swing.
|Journal Publication
Sustainability

Microplastics: Tackling the invisible enemy

Microplastics come from countless sources and have a large impact on the environment. Scientists are working hard to combat this growing problem.
|Insights Report
Drug Discovery

Expedited FDA designation of breakthrough therapy

The FDA can designate drug candidates as “breakthrough therapies” (breakthrough therapy designation or BTD) for certain drug candidates that demonstrate substantial improvement over available therapies on a clinically significant endpoint.
|Infographic
Biotechnology

Exosomes – nature's lipid nanoparticle, a rising star in drug delivery and diagnostics

Exosomes – nature's lipid nanoparticle, a rising star in drug delivery and diagnostics
|Journal Publication
Biotechnology

Exosomes: Reshaping drug delivery and diagnostics

Exosomes are nature’s lipid nanoparticles and their unique physical properties will unlock new applications in drug development, delivery and diagnostic applications in the future
|Insights Report
Drug Discovery

Bioorthogonal chemistry and its applications

Bioorthogonal chemistry is a set of methods that use the chemistry of non-native functional groups to analyze biology in living organisms.
|Journal Publication
Emerging Science

Key insights on click chemistry and bioorthogonal chemistry

Learn about the basics of click chemistry and bioorthogonal chemistry that was recently awarded the 2022 Nobel Prize in Chemistry. Read about emerging trends, insights on publication trends, and future applications of bioorthogonal chemistry.
|Article
Emerging Science

Infographic - Bioorthogonal Chemistry's Path to the Nobel Prize

Timeline showing key reactions and applications culminating in 2022 Nobel Prize in Chemistry
|Infographic
Drug Discovery

How mRNA COVID-19 vaccines work to fight COVID-19

When mRNA (messenger RNA) vaccines are injected into a patient, tiny lipid vesicles transport mRNA molecules through the body fluids and merge with immune cells, called antigen-presenting cells (APCs).
|Video
Drug Discovery

Targeting ACE2 for treatments of COVID-19

Scientists are searching ways to stop the spread of COVID-19, and the ACE2 receptor is one of the most promising targets.
|Video
Sustainability

Bio-based Polymers: A Green Alternative to Traditional Plastics

With over 90% of the world’s plastics production requiring fossil fuels, bio-based polymers generated from renewable sources have substantial benefits over traditional plastics – from reducing CO2 emissions, increased biodegradability, and less dependence on fossil fuels. Learn more in our landscape
|Insights Report
Sustainability

Lithium ion battery recycling

Learn more about the scientific challenges, emerging technologies, and the financial and environmental implications for recycling lithium ion batteries.
|Insights Report
Drug Discovery

Bioorthogonal chemistry: A review of its diverse applications in science and medicine

Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms.
|Insights Report
Digital R&D

Addressing sustainability of the global patent system: the role of AI in enhancing productivity

This whitepaper explores challenges and opportunities for worldwide patent offices as they seek to ensure sustainability and future growth. It focuses on the application of artificial intelligence-enabled workflow solutions to enhance productivity and patent quality.
|Insights Report
Digital R&D

Predicting new chemistry: Impact of high-quality training data on prediction of reaction outcomes

Scientists at Bayer expand their understanding into new, useful chemistry by improving the predictive power of a synthesis planning model with scientist-curated reactions from CAS.
|Insights Report
Drug Discovery

Accelerating Discovery: COVID-19 Vaccine Breakthroughs and their Future Impact

This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.
|Insights Report
Drug Discovery

Accelerating discovery: COVID-19 vaccine breakthroughs and their future impact

This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.
|Insights Report
Drug Discovery

How molecular glues are connecting targeted protein degradation to the clinic

Targeted protein degradation is a novel and quickly expanding drug discovery strategy. It is a new way of utilizing disease-causing proteins to attack severe illnesses, which has the potential to be used among more serious illnesses, such as cancer or neurodegenerative diseases.
|Journal Publication
Drug Discovery

The Landscape of Artificial Intelligence in Chemistry and Opportunities for Growth

Artificial intelligence (AI) and machine learning have been growing exponentially over the last decade, but how has the field of Chemistry evolved with this emerging trend?
|Insights Report
Drug Discovery

RNA-Derived Medicines: A review of the research trends and developments

The use of RNA in therapeutics has the potential to revolutionize medicine. This white paper highlights the emerging trends in the industry.
|Insights Report
Drug Discovery

Lipid Nanoparticles: Past, Present, and Future Opportunities

Lipid nanoparticles play critical roles in mRNA vaccines for treating COVID-19, but their use is not new. Read about past, present, and future opportunities.
|Insights Report
Drug Discovery

The progress and promise of RNA medicine─An arsenal of targeted treatments

The last decade has seen a dramatic shift towards RNA-based medicine. Rapid success in developing lipid-RNA nanoparticles for COVID-19 mRNA vaccines, along with several approved drugs, has propelled RNA to the forefront of pharmaceutical research and development. Explore this revolutionary trend.
|Journal Publication
Sustainability

A review of materials research for a green hydrogen economy

Many technologies have been researched with an eye toward enabling a hydrogen economy.
|Journal Publication
Sustainability

Bio-based polymers as an alternative to fossil fuel plastics

Most synthetic polymers are derived from fossil fuel resources, whose scarcity and imbalanced global distribution can affect plastics producers. Bio-based polymers, obtained from renewable biomass resources, have received wide attention in the past two decades.
|Journal Publication
Drug Discovery

Knowledge graphs accelerate COVID-19 therapies

This white paper details the CAS Biomedical Knowledge Graph and shows how it was used in drug discovery for COVID-19.
|Insights Report
Sustainability

How scientists are restoring carbon balance in the environment

While human capabilities have only increased due to recent technological and medical advances, they have significantly contributed to the release of around 830 gigatons of CO2 into the atmosphere in just the last 30 years alone.
|Journal Publication
Biotechnology

Intrinsically disordered proteins: perspective on COVID-19 infection and drug discovery

It turns out that these intrinsically disordered proteins may be the key to better overcoming diseases in neurodegeneration, diabetes, cardiovascular disease, amyloidosis, genetic diseases, and cancer.
|Journal Publication
Sustainability

Readdressing the balance: Exploring research trends in carbon dioxide sequestration

Learn more about carbon capture, storage, and reduction in our landscape view of this emerging research with unique insights.
|Insights Report
Sustainability

The regulatory environment for lithium-ion battery recycling

Lithium-ion batteries (LIBs) are commonly used in a variety of consumer products, including cellular phones, laptop computers, and more recently, electric and hybrid vehicles.
|Journal Publication
Sustainability

Lithium-ion battery recycling: Overview of techniques and trends

As the production and usage of lithium-ion batteries (LIBs) has increased exponentially, their manufacturing and disposal have become subjects of political and environmental concerns.
|Journal Publication
Drug Discovery

Knowledge graph-based approaches to drug repurposing for COVID-19

The COVID-19 pandemic has motivated researchers across the globe to find effective drugs and therapeutics for treating the disease.
|Journal Publication
Drug Discovery

Inteligencia artificial en química: tendencias actuales y direcciones futuras

En los últimos años, la aplicación de la IA a la química ha crecido rápidamente. Si bien ha habido mucha publicidad sobre la IA utilizada de esta manera, no ha habido muchos análisis en profundidad sobre su uso y desarrollo en el campo de la química.
|Journal Publication
Drug Discovery

The research landscape and advancement of lipid nanoparticles

Lipid nanoparticles (LNPs) have emerged as promising vehicles to deliver a variety of therapeutics in the pharmaceutical industry. Liposomal drugs, based on an earlier version of LNPs, have already been approved and applied to medical practice.
|Journal Publication
Drug Discovery

A review of the global efforts on COVID-19 vaccine development

This report reviews Covid-19 vaccine research, compares the underlying technologies, the use of adjuvants and delivery systems in their application, and provides a perspective on their future direction.
|Journal Publication
Safety

Ammonium nitrate safety

This in-depth CAS Insights Report discusses the chemical properties of ammonium nitrate, its hazards and safety rules, and provides a useful resource for those involved in the handling and storage of this compound.
|Insights Report
Drug Discovery

Building A Foundation For Profitable Digital Transformation in Sci-Tech R&D

Artificial Intelligence may be hot right now, but the smart money is investing in data. See how CAS solutions can help.
|Insights Report
Drug Discovery

QSAR machine learning models and their applications for identifying potential COVID-19 therapeutics

To identify potential anti-SARS-CoV-2 therapeutics, CAS scientists are building machine-learning predictive models to identify novel drug candidates for the viral targets 3 chymotrypsin-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp).
|Journal Publication
Drug Discovery

Potential therapeutic agents and associated bioassay data for COVID-19 and related human coronavirus infections

This report aids COVID-19 therapeutic research by summarizing protein targets and potential drug candidates. It includes bioassay and structure-activity relationship data from scientific and patent literature for COVID-19 and related viral infections. Explore key insights to support ongoing drug dev
|Journal Publication
Drug Discovery

Assay techniques and test development for COVID-19 diagnosis

To provide a better understanding and comparison of the diagnostic tests available in the fight against COVID-19, CAS has produced a report summarizing the basic principles of molecular and serological assays being used in diagnostic tests for SARS-CoV-2.
|Journal Publication