Agentic AI built to complement your CAS SciFinder® experience.

While most AI tools learn from language, CAS Newton℠ draws on the same peer-reviewed scientific literature and data sources as CAS SciFinder. This allows you to experience the same conversational capabilities as other large language models, but with traceable answers from sources you trust.

Login to CAS SciFinder
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CAS Newton is built to solve challenges.

See how science-smart agentic AI can analyze chemical structures, biological relationships, and curated research data to answer complex scientific questions.

"CAS Newton will dramatically alter my workflow and provide insights that could not be found with traditional searching. For example, I recently searched for ideas on how to label our lead molecule with PET labels. CAS Newton used a database that I would not have considered at all."
Jukka Hiltunen
Project Manager, Glykos Finland

Choosing a route means weighing yields, conditions, and scalability across thousands of reactions.

"What stands out about CAS Newton is that unlike general-purpose AI models that lean heavily on language probabilities, it can execute multi-step research autonomously. For example, if a researcher asks about a complex multi-part synthesis or chemical property prediction, it handles that in a way that feels meaningfully different from what you'd get elsewhere."
R&D Manager / Team Leader
Medium Pharmaceutical Company

Streamline your patent research with the assistance of science-smart AI to uncover insights and opportunities that drive research direction.

"We used CAS Newton to identify scalable purification alternatives for a specific patent search. Traditional keyword queries failed to capture hidden reaction details across large reference sets, CAS Newton successfully located a specific method within the prior art, eliminating tedious manual sifting and accelerating our Freedom to Operate assessment."
Legal Specialist
International Diversified Chemicals Company

Three steps for having your first conversation:

1
Log in to CAS SciFinder
2
Choose the "Ask CAS Newton" option
3
Type your question in your native language

Interact conversationally in your native language

CAS Newton removes barriers to understanding and enables you to contextualize the direction of your thinking to take full advantage of 150 years of trusted scientific knowledge.

Try CAS Newton today and drive your research forward!

Frequently asked questions

How do I access CAS Newton?

Will my data be used to train AI models?

How reliable are AI outputs in CAS Solutions? Are there hallucinations?

Where can I learn how to use CAS Newton?