Trusted scientific content, everywhere your research happens
CAS Connections brings the CAS Content Collection™ and CAS Newton℠ agentic AI directly into your existing research platforms, AI environments, and agentic workflows — so the science your organization depends on is available wherever decisions are made.
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R&D teams work across many platforms. CAS makes their outputs smarter, faster, and more reliable.
Every extra step between a researcher and reliable scientific information is a gap where discovery stalls. Fragmented access to scientific knowledge introduces risk into AI-generated answers and forces researchers to choose between the tools they know and the information they need.
Accelerate discovery
Authoritative chemical and biological knowledge surfaces earlier in the process - right when your researchers need it.
Strengthen AI outputs
AI answers grounded in curated, verifiable scientific sources so every recommendation can be cited and defended.
Support compliance and IP
Auditable, traceable access to CAS content within your secure environment — consistent with the rigorous standards pharma and chemical R&D requires.
Reduce redundant work
Reduce repeated searches and manual data transfer across systems — researchers stay focused on science.
What CAS Connections delivers
Multiple integration paths. One trusted source.
CAS Connections embeds CAS content and CAS Newton agentic AI into your existing tools, agents, and workflows to meet your organization wherever its infrastructure lives. Every integration draws on the full depth of our trusted, curated scientific knowledge.
Data Access
CAS content in your platforms and pipelines
Query CAS content programmatically. Responses feed directly into ELNs, LIMS, discovery platforms, dashboards, and custom applications — structured, reliable data delivered at the point of decision.
AI Integration
Trusted scientific knowledge inside existing AI tools
CAS Newton connects as a knowledge source inside existing AI platforms, so the intelligence powering those tools is grounded in curated, citable content.
Agentic Workflows
CAS Newton in your agent ecosystem
CAS Newton operates within your organization's own multi-agent workflows — passing context and outputs across your tools, pipelines, and automated systems. As your agentic architecture evolves, you can trust that findings and conclusions are backed by scientific knowledge and insights.
Need more?
CAS Custom Services
For organizations whose needs go beyond CAS Connections — a customized data feed, proprietary R&D data integration, or custom AI/ML development — CAS Custom Services builds purpose-built solutions around your environment.
Growing systems
Already integrating with platforms your teams know
CAS Connections is expanding across the R&D software landscape. The platform investments your organization has already made become more valuable with CAS content and AI available inside them.
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Who it serves
From bench to pipeline to agent
Researchers
Prior art, synthesis routes, safety data, and reaction history surface directly within ELNs, LIMS, and discovery platforms with minimal interruptions or separate lookups.
Data Scientists
Query CAS content programmatically via API. Feed curated scientific data directly into models, dashboards, and analytical workflows combined with your organization's proprietary data in a secure environment.
AI Agents
CAS Newton provides agent-to-agent interaction via MCP to deliver verified, cited scientific intelligence to AI systems mid-workflow. As your AI ecosystem evolves, CAS evolves with it.
The content behind it
The CAS Content Collection
Over 150 years of human-curated scientific knowledge now available in your workflows.
CAS REGISTRY®
300M+ substances, uniquely identified.
CAS Reactions
Synthesis routes and reaction data, searchable by structure.
CAS References
Scientific literature across chemistry, biology, and pharmacology — curated since 1907.
CAS Patents
Patent data linked to substances and sequences — supporting FTO and IP workflows.
Security and Trust
A secure environment from the start
CAS Connections is designed to meet the security and compliance expectations of enterprise R&D with the controls and auditability that give IT, legal, and research leadership confidence in every integration.
Deploys in your secure environment
CAS Connections operates within your organization's infrastructure. Your IT and compliance teams control access, configuration, and deployment so your organization's proprietary data stays in your environment.
Fully auditable AI outputs
CAS Newton response are tied to a cited, verifiable source from the CAS Content Collection so answers can be traced, reviewed, and defended for IP, regulatory, and compliance purposes.
Your data stays yours
Queries made through CAS Connections are never shared across organizations or used to train AI models. Your proprietary research data and internal knowledge remain entirely within your control.
Powered by CAS Newton
Science-smart agentic AI, purpose-built for research
CAS Newton is built for scientific reasoning. It handles complex, multi-part research questions and returns cited, verifiable answers grounded in the CAS Content Collection. Through CAS Connections, that same capability runs within partner platforms, held to the same standards of accuracy and auditability your organization requires.
Learn about CAS Newton →Bring trusted science into your R&D stack
Talk to a CAS specialist about integrating CAS Connections into your organization's platforms.
Frequently asked questions