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The power of the human connection

The scientists who build the CAS Content Collection™ are united by a shared purpose: accelerating discoveries that improve lives.  
Every day, they curate, connect, and analyze global literature, knowing their work impacts thousands of research projects worldwide.

Expert curation delivers reliable  data

Hundreds of scientists with expertise spanning chemistry, biology, materials science, and specialized fields curate the CAS Content Collection.  

Our curation model combines:

  • Expert judgment: Understanding context, catching errors, making critical connections
  • Advanced technology: AI and machine learning to process volume and identify patterns
  • Rigorous quality: Multi-layer validation to ensure every data point is accurate

While technology helps us process 100,000+ documents daily, human intelligence ensures the connections are meaningful and the insights are trustworthy.

Explore CAS data types
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Uniting Global Knowledge

Scientific publications are published worldwide in diverse formats, languages, and styles. Critical insights are buried in dense documents, trapped in images and diagrams, expressed in specialized notation, or disclosed in languages most researchers can't read.

Talented CAS scientists and researchers transform what others cannot. What the scientific world publishes in fragments, they deliver as structured, connected, decision-ready knowledge.

The CAS Content Collection curation process

How unstructured, disconnected research becomes a unified, searchable resource

1

Aggregate

Gather publications from journals, patent offices, and authoritative databases across disciplines.
01
Scientific Journals Patent Offices Authoritative Databases
2

Extract

Scientists identify and capture key data: substances from images, reactions from schemes, sequences from tables, and insights from text.
02
Substances from images Reactions from schemes Sequences from tables Insights from text
3

Standardize

Convert diverse formats into consistent, machine-readable structures using controlled vocabularies and authority constructs.
03
4

Connect

Link related concepts across documents: substances to reactions, diseases to targets, patents to prior art, creating a knowledge graph spanning over a century.
04
Substances Reactions Patents Diseases Targets Prior Art
5

Validate

Multi-layer quality checks ensure accuracy, consistency, and completeness before data enters the collection.
05
PENDING Accuracy Consistency Completeness

The result

A unified knowledge base created for scientists by scientists where a single query draws on a century of curated, connected scientific knowledge across disciplines, languages, and decades.

FAQ

Who uses the CAS Content Collection?

How is the CAS Content Collection different from CAS REGISTRY®?

What is the CAS Content Collection?

How often is the CAS Content Collection updated?

Have another question?

We are here to help. If you need assistance with CAS data, products, access, or account support, you can reach the CAS Customer Center for personalized help. CAS Customer Center is the central source for all inquiries, including product questions, account support, billing, documentation, and search strategy guidance.

Real world impact

Two CAS Custom Services brochures highlighting a solution success story about custom-curated machine learning training datasets that accelerate optimization of organic synthesis workflows, featuring scientists working in laboratory settings.

Conjunto de dados personalizado para treinamento de machine learning acelera a otimização do fluxo de síntese orgânica

Robotic arm operating in an advanced automated laboratory or manufacturing environment, surrounded by machinery and transparent processing chambers, with the Chemlex logo visible in the corner.

Estabelecendo novos padrões de precisão preditiva em IA com dados de treinamento personalizados

Custom knowledge management system reduces search time from hours to minutes