How molecular glues are connecting targeted protein degradation to the clinic


Targeted protein degradation is a novel and quickly expanding drug discovery strategy. It is a new way of utilizing disease-causing proteins to attack severe illnesses, which has the potential to be used among more serious illnesses, like cancer or neurodegenerative diseases.

This study from the American Chemical Society utilizes the CAS Content Collection and recent research on protein degraders to provide more nuanced insight into molecular glue as a tool for new drug discovery. It analyzes the advantages and disadvantages of molecular glue as a reference to support further research.