Database News

CAS REGISTRYSM BLAST® Upgrade Improves Search Capabilities and Results Ranking

The BLAST software used in CAS REGISTRY BLAST was upgraded to version 2.2.29. CAS REGISTRY BLAST is the integrated software and data solution created by CAS for sequence searching in STN Express® and STN® on the WebSM. The backbone to CAS REGISTRY BLAST is BLAST software, developed by the U.S. National Center for Biotechnology Information (NCBI). 

Key changes in this version are as follows:

  • Expanded search capabilities: It is now possible to search proteins that include J (leucine or isoleucine) and/or O (pyrrolysine) residues.
  • Better results ranking: Sequences with gaps are now scored differently. Instead of a score for each individual sequence separated by a gap, a score is computed for the entire sequence including the gap. This often results in gapped sequences appearing lower in the BLAST report than they would have before.

CAS REGISTRY BLAST continues to provide unique value to searchers by covering sequences from patents as well as journals, and by providing access to records in CAplusSM where the sequences were reported.

STN Express and STN on the Web Releases Enhance Precision of Structure Searching Results and Efficiency

Effective May 27, 2014:

  • A maintenance release of STN Express, Version, is available on the STN® License and Download Software site
  • A new Structure Plug-in is available within STN on the Web

These new releases provide enhanced precision of structure searches involving G-groups, and increase structure search efficiency. We recommend that structure searchers (especially those using STN Express 8.5.2) immediately take advantage of the new releases.

New AUPB Field Supplements Author Information Provided in EmbaseTM, Embase AlertTM, MEDLINE® and SciSearch®

The Embase, Embase Alert, MEDLINE and SciSearch databases each include organizational affiliation (corporate source) data for all authors, as available.

For multi-authored works referenced in these databases, the order in which author names appeared in the original source document is not always evident.

Effective June 29, 2014, the AUPB (Authors in Publication Order) field will provide AUPB data for search and custom display. It has been added to the ALL and IALL formats in each of these databases.

Additional Experimental Spectra Now Available in CAS REGISTRY on STN

Effective May 2014, CAS enhanced its collection of experimental spectra available in CAS REGISTRY. In addition to the 1.3 million experimental spectra already available, CAS added more than 17,000 NMR spectra to CAS REGISTRY. The specific atoms covered are carbon, hydrogen, fluorine, nitrogen and phosphorus. The breakdown is as follows:

Type of Spectra      ACD Labs
Carbon-13 NMR           >8,900
Proton NMR                  >5,200
Fluorine-19 NMR          ~2,000
Nitrogen-15 NMR            >100
Phosphorus-31 NMR    ~1,000

The source of the new spectra is ACD Labs.


CAplus Cited References:  400 Million Strong... and Growing!

CAplus has long been a major source of cited reference information. Cited references in CAplus originate from the bibliography at the end of a journal article, as well as from patents, which reference other patents as well as non-patent literature. CAplus recently reached a major milestone when it added its 400 millionth cited reference! Thousands of new cited references are added to CAplus every week. Click here to find more information on CAS coverage of cited references.

Looking at the most frequently cited publications (or articles), we find that many of them discuss what are now standard laboratory protocols and procedures, and tools for scientific data analysis. Their topics include: protein measurement and identification, RNA isolation, and sequence searching. Here are the top ten most cited references, as of June 2014:

1.     Title: A rapid and sensitive method for the quantitation of microgram
        quantities of protein utilizing the principle of protein-dye binding.
        Author: Bradford, Marion M.
        Organizational Affiliation: Dep. Biochem., Univ. Georgia,
        Athens, GA, USA
        Source: Analytical Biochemistry (1976), 72(1-2), 248-54
        Number of times cited: 92,854 

2.     Title: Cleavage of structural proteins during the assembly of the
        head of bacteriophage T4.
        Author: Laemmli, U. K.
        Organizational affiliation: MRC Laboratory of Molecular Biology,
        Cambridge, UK
        Source: Nature (London, United Kingdom) (1970), 227(5259), 680-
        Number of times cited: 79,618 

3.     Title: Protein measurement with the Folin phenol reagent
        Authors: Lowry, Oliver H.; Rosebrough, Nira J.; Farr, A. Lewis;
        Randall, Rose J.
        Organizational affiliation: Washington Univ., St. Louis, MO
        Source: Journal of Biological Chemistry (1951), 193, 265-75
        Number of times cited: 60,918 

4.     Title: Density-functional thermochemistry. III. The role of exact
        Author: Becke, Axel D.
        Organizational affiliation: Dep. Chem., Queen's Univ.,
        Kingston, ON, K7L 3N6, Can.
        Source: Journal of Chemical Physics (1993), 98(7), 5648-52
        Number of times cited: 49,294 

5.     Title: Development of the Colle-Salvetti correlation-energy formula
        into a functional of the electron density
        Authors: Lee, Chengteh; Yang, Weitao; Parr, Robert G.
        Organizational affiliation: Dep. Chem., Univ. North Carolina,
        Chapel Hill, NC, 27514, USA
        Source: Physical Review B:  Condensed Matter and Materials
        Physics (1988), 37(2), 785-9
        Number of times cited: 42,576 

6.     Title: Generalized gradient approximation made simple
        Authors: Perdew, John P.; Burke, Kieron; Ernzerhof, Matthias
        Organizational affiliation: Dep. Phys. Quantum Theory Group,
        Tulane Univ., New Orleans, LA, 70118, USA
        Source: Physical Review Letters (1996), 77(18), 3865-3868
        Number of times cited: 37,052 

7.     Title: Gapped BLAST and PSI-BLAST: a new generation of
        protein database search programs
        Authors:  Altschul, Stephen F.; Madden, Thomas L.;Schaffer,
        Alejandro A.; Zhang, Jinghui; Zhang, Zheng;  Miller, Webb;
        Organizational affiliation: Natl. Cent. Biotechnol. Information,
        Natl. Library Med., Natl. Inst.Health, Bethesda, MD, 20894, USA
        Source: Nucleic Acids Research (1997), 25(17), 3389-3402
        Number of times cited: 35,774 

8.     Title: CLUSTAL W: improving the sensitivity of progressive multiple
        sequence alignment through sequence weighting, position-specific
        gap penalties and weight matrix choice
        Authors: Thompson, Julie D.; Higgins, Desmond G.; Gibson,
        Toby J.
        Organizational affiliation: European Molecular Biology laboratory,
        Heidelberg, D-69012, Germany
        Source: Nucleic Acids Research (1994), 22(22), 4673-80
        Number of times cited: 33,197 

9.     Title: Single-step method of RNA isolation by acid guanidinium
        thiocyanate-phenol-chloroform extraction
        Authors: Chomczynski, Piotr; Sacchi, Nicoletta
        Organizational affiliation: Lab. Biochem. Metabol., NIDDK,
        Bethesda, MD, 20892, USA
        Source: Analytical Biochemistry (1987), 162(1), 156-9
        Number of times cited: 32,340 

10.   Title: Basic local alignment search tool
        Authors: Altschul, Stephen F.; Gish, Warren; Miller, Webb;
        Myers, Eugene W.; Lipman, David J.
        Organizational affiliation: Natl. Cent. Biotechnol. Inf., Natl. Library
        Med., Bethesda, MD, 20894, USA
        Source: Journal of Molecular Biology (1990), 215(3), 403-10
        Number of times cited: 29,977

June 2014 


Have you heard about STN Global Value Pricing?

STN Global Value Pricing delivers unlimited STN access for your entire organization at a fixed price, with predictable renewal costs. Built upon the successful STN Fixed Fee pricing program, Global Value Pricing incorporates customer feedback and recent market trends to empower users to maximize the value STN creates for their entire organization. For more information on STN Global Value Pricing, click here.

Here are two ways unlimited STN access can add value for your organization:

Try new STN! Available exclusively to fixed fee and Global Value Pricing customers, new STN leverages cutting-edge technology to deliver an intuitive, powerful interface designed for professionals. New STN revolutionizes patent searching by making it possible to quickly and efficiently explore the unique content STN offers to find answers and develop unique insights not possible before. New STN benefits new and experienced STN searchers with:

  • Faster search execution - up to 15 times faster for some searches 
  • Limitless search power - no size restrictions on queries or answer sets 
  • Unique Extended Patent Family Table 
  • Project-oriented workflow 

Explore the unique features of new STN here.

Stay up-to-date with STN current awareness alerts. Alerts automatically deliver customized updates that provide stakeholders with the most current perspective, giving your organization a decisive information advantage in areas such as competitive intelligence, strategic planning and IP portfolio management. Be the first to know about newly disclosed substances, the latest research breakthroughs and changes in the patent landscape. Unlimited alerts are included for all Global Value Pricing customers. Learn more about STN alerts here.


scienceIPScience IP®, the CAS Search Service, contributes monthly articles describing best practices and useful information from real searches.

This month's article is titled "Use of Multiple Repeating Groups in New STN Allows for Precise Broadening of Structure Queries." 

The enhanced search power of new STN provides opportunities for greater structure search precision, even for broad queries, allowing you to fully represent the specific requirements of each search project. For example, the enhanced search capacity of new STN supports structure queries that include multiple repeating groups. This allows you more flexibility to add controlled variability to find similar substances to a substance of interest. The broad results set can then be narrowed for a specific use or application. Read more here.

Faced with a challenging search or require comprehensive results? Contact the expert research staff at Science IP.


You can find upcoming training on the Training & Events Calendar. The event titles provide a full description of the event and registration links. For simplified use, view the calendar by month or filter by event type.

July 8, 2014
9:00 am EDT
Asian Patent Publication Coverage on STN - A case study

July 24, 2014
2:00 pm EDT
Asian Patent Publication Coverage on STN - A case study

July 29, 2014
1:00 pm EDT
Tips for Searching Chemical Names on STN

Register for all of the training classes here.

New STN Training - Get started with new STN here. 


July 12-15, 2014
San Antonio, TX
AALL Annual Meeting

August 10-14, 2014
San Francisco, CA
248th ACS National Meeting & Exposition

September 29-October 1, 2014
New Brunswick, NJ
PIUG 2014 Northeast Conference

October 23-25, 2014
Washington, DC
AIPLA Annual Meeting