Chris Lipinski earned his Ph.D. in physical organic chemistry from the University of California, Berkeley. Following his post-doctoral fellowship at the California Institute of Technology, Dr. Lipinski spent more than 30 years at Pfizer as a Senior Research Fellow where he developed the renowned, rule of 5. He is currently serving as a Scientific Advisor for Melior Discovery and consultant through his own company, Christopher A. Lipinski, Ph.D., LLC.
Latest Content from Chris Lipinski, Ph.D.
June 7, 2019
To the rule of 5 and beyond? How Dr. Chris Lipinski gained new insights into drug discovery
You are probably familiar with the 'rule of 5' (Ro5), the set of guidelines I introduced in 1997 to help reduce the attrition rate in drug discovery. It proved to be a useful strategy for selecting candidates with good oral bioavailability properties. However, some of the biggest challenges in drug discovery now require us to think beyond our current design space.