| Introduction |
This topic describes how to locate organic synthetic methods based on chemical functional groups using Explore Reactions.
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| When to use |
Use functional group searching when you want to find methods used to carry out a broadly defined transformation.
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| Database content |
Functional group searching accesses the records that focus on synthetically useful procedures. For example:
- New, more convenient, or improved synthetic methods
- Procedures for improving yields
- Applications of new reagents
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| Reaction precision tools |
Tools are available to control the precision of functional group search results:
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When you want to |
Use this tool |
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Draw a reaction arrow and automatically define the participant roles:
- reactant/reagent on left
- product on right
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Reaction Arrow tool
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| Change or add the role a reaction participant plays in a reaction |
Reaction Role tool
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Example |
Using cyclic ketones as the starting material, locate preparations of compounds with this structure:
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| How to |
Follow these steps to locate a functional group transformation. |
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Step |
Do this |
| 1 |
Click  . |
| 2 |
Click the structure drawing image to open the editor.
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| 3 |
Draw the reaction transformation of interest.
Apply the following tools to control answer precision:
- Functional Group tool
 to define the starting material
- Reaction Arrow and Reaction Role tools to define roles for the reaction participants
- Lock Rings tool to control ring formation
- Lock Atoms tool to control substitution
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| 4 |
On the right of the Reaction Editor, select the substructure option. Click OK.
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| 5 |
(Optional) Specify any limits you with to apply. Click Search.
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| 6 |
Reaction matches display in summary format.
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When you want to see |
Do this |
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The full reaction record, including all steps in multi-step reactions.
OR
Information about a specific reaction participant, such as:
- Reactions in which a substance participates
- References about the substance
- Substance detail, e.g., CAS Registry Number, names, or properties
- Commercial sources
- Regulatory information
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Click Reaction Detail.
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| The reference citing the reaction |
Click the reference title link (located below the reaction summary). |
| A smaller set of more precisely defined reaction matches |
Use the Analysis and Refine tabs.
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Updated: 10/5/2009 11:06:44 AM
