| Introduction |
This topic describes how to locate organic synthetic methods using Explore Reactions.
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| When to use |
Use full reaction searching when you want to locate organic synthetic pathways with specific structural transformations. Structures can be specified on:
- Both sides of the reaction arrow
- The reactant side of the reaction arrow only
- The product side of the reaction arrow only
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| Behind the scenes |
Full reaction searching accesses records that focus on synthetically useful procedures. For example:
- New, more convenient, or improved synthetic methods
- Procedures for improving yields
- Applications of new reagents
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| Preview |
Locating full reactions containing a structural transformation of interest is a two-step process:
- Locate relevant reactions for the transformation of interest
- (Optional) Refine results using precision criteria
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| Example |
Locate reactions matching the following structural transformation:
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| Locate relevant reactions |
Follow these steps to locate a structural transformation: |
| Step |
Do this |
| 1 |
Click  . |
| 2 |
Click the structure drawing image to open the editor.
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| 3 |
Draw the reaction transformation of interest.
Tip: Apply the following tools to control answer precision:
- Lock Rings tool to control ring formation
- Reaction Arrow tool to define the reaction participants
- Atom Mapping tool to map an atom between reactant and product
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| 4 |
On the right of the Reaction Editor, select the Substructures option. Click OK.
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| 5 |
(Optional) Limit reactions by any criteria you wish to apply, including selecting solvents. Click Search.
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| 6 |
Reaction matches display in summary format.
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When you want to see |
Do this |
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The full reaction record, including all steps in multi-step reactions.
OR
Information about a specific reaction participant, such as:
- Reactions in which the specific substance participates
- References about the substance
- Substance detail, e.g., CAS Registry Number, names, or properties
- Commercial sources
- Regulatory information
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Click Reaction Detail.
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The reference citing the reaction |
Click the reference title link (located below the reaction summary). |
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A set of related reactions with similar structural features |
- Click Similar Reactions within summary format
- Click Get Reactions within detail format
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A smaller set of more precisely defined reaction matches
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Use the Analysis and Refine tabs.
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Updated: 10/6/2009 7:15:26 AM
