| Introduction |
This section describes how to locate organic synthetic methods based on chemical functional groups using Explore by Chemical Substance or Reaction.
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| When to use |
Use functional group searching when you want to find methods used to carry out a broadly defined transformation.
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| Database content |
Functional group searching accesses the CASREACT database. Records in CASREACT focus on synthetically useful procedures. For example:
- New, more convenient, or improved synthetic methods
- Procedures for improving yields
- Applications of new reagents
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| Reaction precision tools |
Tools are available to control the precision of functional group search results:
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When you want to |
Use this tool |
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Draw a reaction arrow and automatically define the participant roles:
- reactant/reagent on left
- product on right
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Reaction Arrow tool
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| Change the role a reaction participant plays in a reaction |
Reaction Role tool
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Example |
Using cyclic ketones as the starting material, locate preparations of compounds with this structure:
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| How to |
Follow these steps to locate a functional group transformation. |
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Step |
Do this |
| 1 |
From the New Task dialog box, click Explore  . |
| 2 |
From the Explore dialog box, click Reaction Structure  . |
| 3 |
The structure drawing window appears. Draw the reaction transformation of interest. Click Get Reactions. Apply the following tools to control answer precision:
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| 4 |
The Get Reactions dialog box appears. Select the substructures option. Click OK.
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| 5 |
The reaction viewer containing all the reaction matches appears.
| When you want to see |
Do this |
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Information about a specific reaction participant, such as
- Reactions in which the specific substance participates (SciFinder subscription users only)
- References about the substance
- Substance detail, e.g., CAS RN, names, or properties
- Commercial sources
- Regulatory information
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- Position the cursor over any structure or CAS RN in a reaction.
- Click.
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| The reference citing the reaction |
Reference: hyperlink |
| A smaller set of more precisely defined reaction matches |
Click Analyze/Refine  .
The Analyze or Refine dialog box appears. Click Refine  .
The Refine by Reaction dialog box appears. Click Chemical Structure, Product Yield, Number of Steps, or Reaction Classification.
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Updated 4/15/2009 11:01:22 AM
to define the starting material
