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CAS indexed 295 chemical substances from this document.
CAS subject entries for this document include: Antibacterial agents; Cytotoxicity; Drug screening; and 4 additional concepts. | |
CAPLUS COPYRIGHT 2008 ACS on STN
| TITLE:
| Anti-MRSA agent discovery using diversity-oriented synthesis |
| AUTHOR(S):
| Thomas, Gemma L.; Spandl, Richard J.; Glansdorp, Freija G.; Welch, Martin; Bender, Andreas; Cockfield, Joshua; Lindsay, Jodi A.; Bryant, Clare; Brown, Derek F. J.; Loiseleur, Olivier; Rudyk, Helene; Ladlow, Mark; Spring, David R. |
| CORPORATE SOURCE:
| Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK |
| SOURCE:
| Angewandte Chemie, International Edition (2008), 47(15), 2808-2812 CODEN: ACIEF5; ISSN: 1433-7851 |
| PUBLISHER:
| Wiley-VCH Verlag GmbH & Co. KGaA |
| LANGUAGE:
| English |
ABSTRACT:Beating the superbugs: Diversity-oriented synthesis using a solid-supported phosphonate unit to synthesize 242 drug-like compds. based on 18 natural-product-like scaffolds led to the discovery of gemmacin. This new structural class of antibiotic is active towards methicillin-resistant Staphylococcus aureus (MRSA).
Updated 1/20/2009 1:38:10 PM
