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Most Intriguing Documents 4Q07-Chemistry and Related Science

Following is one of the journal documents most requested by researchers using CAS online services.

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CAS indexed 4 chemical substances from this document. CAS subject entries for this document include: Cytotoxicity; Dissolution; Drug transport; and 4 additional concepts

CAPLUS COPYRIGHT 2008 ACS on STN

TITLE:	pH-Sensitive Polymer Nanospheres for Use as a Potential Drug Delivery Vehicle
AUTHOR(S):	Jung, Jua; Lee, In-Hyun; Lee, Eunhye; Park, Jinho; Jon, Sangyong
CORPORATE SOURCE:	Research Center for Biomolecular Nanotechnology, Department of Life Science, Gwangju Institute of Science and Technology (GIST), Gwangju, 500-712, S. Korea
SOURCE:	Biomacromolecules (2007), 8(11), 3401-3407 CODEN: BOMAF6; ISSN: 1525-7797
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
We report the development and characterization of pH-sensitive poly(2-tetrahydropyranyl methacrylate) [poly(THPMA)] nanospheres and demonstrate their feasibility as an effective drug delivery vehicle. Poly(THPMA) nanospheres were prepd. using either the double emulsion or single emulsion method for the encapsulation of, resp., water sol. (rhodamine B) or org. sol. (paclitaxel) payloads. The resulting nanospheres showed pH-dependent dissoln. behavior, resulting in significant morphol. changes and loss of nanoparticle mass under mild acidic conditions (pH 5.1) with a half-life of 3.3 days, as compared to physiol. condition (pH 7.4) with a half-life of 6.2 days. The in vitro drug release profile of the paclitaxel-loaded poly(THPMA) nanospheres revealed that the rate of drug release in pH 5.1 acetate buffer was relatively faster than that in pH 7.4 HEPES buffer. Furthermore, poly(THPMA) nanospheres showed lower cytotoxicity and higher cellular uptake as compared to the FDA-approved PLGA-based nanospheres currently in clin. practice.