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CAS indexed 69 chemical substances from this document.
CAS subject entries for this document include: Solid phase synthesis supports; Sialic acids; Drug delivery systems; and 9 additional concepts. | |
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CAPLUS COPYRIGHT 2008 ACS on STN
| TITLE:
| Functionalization of polymers by click chemistry |
| INVENTOR(S):
| Haddleton, David; Mantovani, Guiseppe; Ladmiral, Vincent |
| PATENT ASSIGNEE(S):
| Warwick Effect Polymers Ltd., UK |
| SOURCE:
| PCT Int. Appl., 114pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2007104948 A2 20070920 WO 2007-GB840 20070312
WO 2007104948 A3 20071206
W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH,
CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD,
GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN,
KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, MG, MK, MN,
MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS,
RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ,
UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
RW: AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE,
IS, IT, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR, BF,
BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG, BW,
GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW, AM, AZ,
BY, KG, KZ, MD, RU, TJ, TM, AP, EA, EP, OA
ABSTRACT:
The application discloses a process for making a polymer having pendant side groups comprising: (i) polymg. an olefinically unsatd. monomer functionalized with (a) an azide group optionally protected by a protecting group, or (b) an alkyne group optionally protected by a protecting group, by living radical polymn., most preferably RAFT, transitional metal mediated living radical polymn. (TMM-LRP) and/or atom transfer radical polymn., to produce a polymer intermediate; (ii) removing, when present, at least a portion of the total no. of protecting groups from the polymer intermediate; (iii) reacting the polymer intermediate with at least one pendant side group moiety functionalized with (a) an alkyne group or (b) an azide group resp. so that the alkyne and azide groups react to attach the pendant side group to the polymer. The pendant side group may be one or more sugars, substituted or nonsubstituted alkyl groups, substituted or nonsubstituted polyalkylene glycol groups, glycerol groups, lipopolysaccharide groups or phospholipid groups. Processes for making supports comprising pendant side groups, and polymers and supports prepd. by the method are also disclosed. A typical polymer with pendant side groups is manufd. by polymn. of 3-(trimethylsilyl)-2-propynyl methacrylate 4 h at 70.degree. in the presence of N-ethyl-2-pyridylmethanimine, benzyl 2-bromo-2-methylpropionate, and CuBr, removal of the trimethylsilyl group, and reaction of the resulting intermediate with 1-.beta.-azido-2,3,4,6-tetraacetyl-D-galactose 3 days in THF in the presence of diisopropylethylamine, and PPh3CuBr.
Updated 1/25/2008 1:15:05 PM
