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Home   •   Spotlight  •  rlist4q07j  •  Most Requested Journal Articles 4Q07-Chemistry and Related Science (9)

Most Requested Journal Articles 4Q07-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS electronic products.

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CAS indexed 102 chemical substances from this document. CAS subject entries for this document include: Cross-coupling reaction; Esters, reactions; Boronic acids; and 4 additional concepts

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TITLE:	Highly Efficient Monophosphine-Based Catalyst for the Palladium-Catalyzed Suzuki-Miyaura Reaction of Heteroaryl Halides and Heteroaryl Boronic Acids and Esters
AUTHOR(S):	Billingsley, Kelvin; Buchwald, Stephen L.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Journal of the American Chemical Society (2007), 129(11), 3358-3366 CODEN: JACSAT; ISSN: 0002-7863
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
A highly active and efficient catalyst system derived from a palladium precatalyst and monophosphine ligands I or II for the Suzuki-Miyaura cross-coupling reaction of heteroaryl boronic acids and esters has been developed. This method allows for the prepn. of a wide variety of heterobiaryls in good to excellent yields and displays a high level of activity for the coupling of heteroaryl chlorides as well as hindered aryl and heteroaryl halides. Specific factors that govern the efficacy of the transformation for certain heterocyclic motifs were also investigated.