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Home   •   Spotlight  •  rlist4q07j  •  Most Requested Journal Articles 4Q07-Chemistry and Related Science (3)

Most Requested Journal Articles 4Q07-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS electronic products.

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CAS subject entries for this document include: Cycloaddition reaction; Azides; Alkynes

CAPLUS COPYRIGHT 2008 ACS on STN

 

TITLE:	The growing applications of Click chemistry
AUTHOR(S):	Moses, John E.; Moorhouse, Adam D.
CORPORATE SOURCE:	Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, London, WC1N 1AX, UK
SOURCE:	Chemical Society Reviews (2007), 36(8), 1249-1262 CODEN: CSRVBR; ISSN: 0306-0012
PUBLISHER:	Royal Society of Chemistry
LANGUAGE:	English

ABSTRACT:
A review. Click chem. is a modular synthetic approach towards the assembly of new mol. entities. This powerful strategy relies mainly upon the construction of carbon-heteroatom bonds using "spring-loaded" reactants. Its growing no. of applications are found in nearly all areas of modern chem. from drug discovery to materials science. The copper(I)-catalyzed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold std. of Click chem. due to its reliability, specificity and biocompatibility.