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Most Requested Journal Articles 4Q07-Chemistry and Related Science
Following is one of the journal articles most requested by researchers using CAS electronic products.
CAPLUS COPYRIGHT 2008 ACS on STN
A review. The environmentally amiable route to C-heteroatom bond formation, described by Sharpless as 'click chem.', has become known as a fast, efficient, and reliable approach to the synthesis of novel compds. with desired functionalities. Readily available starting materials must be used in this methodol. and they should be essentially inert to most biol. and org. conditions, including H2O and O2. In this review, the authors cover reactions included in this label such as Huisgen 1,3-dipolar cycloaddns., nucleophilic ring-opening reactions of strained rings such as epoxides and aziridines, and amide synthesis, as well as their applications in org. synthesis, mol. biol., macromol. chem. and materials science. Other topics discussed include click synthesis of epoxides and aziridines, supramol. click chem., liq. crystals, self-assembled monolayers, multicomponent reactions, creating drug candidates under click conditions, click chem. with peptides and proteins and DNA as a participant in click reactions. Updated 1/25/2008 11:43:47 AM
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