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CAPLUS COPYRIGHT 2007 ACS on STN
| TITLE:
| Method of manufacturing solid dispersions |
| INVENTOR(S):
| Nakamichi, Kouichi; Izumi, Shogo; Yasuura, Hiroyuki |
| PATENT ASSIGNEE(S):
| Nippon Shinyaku Company, Limited, Japan |
| SOURCE:
| U.S., 17 pp. CODEN: USXXAM |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
US 5456923 A 19951010 US 1993-129133 19931115
CA 2108575 A1 19921017 CA 1992-2108575 19920414
CA 2108575 C 20021022
WO 9218106 A1 19921029 WO 1992-JP470 19920414
W: AU, BR, CA, FI, HU, JP, KR, NO, RU, US
RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE
AU 9215372 A 19921117 AU 1992-15372 19920414
EP 580860 A1 19940202 EP 1992-907654 19920414
EP 580860 B1 19971022 EP 580860 B2 20041215
R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, MC, NL, SE
JP 2527107 B2 19960821 JP 1992-507772 19920414
AT 159426 T 19971115 AT 1992-907654 19920414
ES 2111065 T3 19980301 ES 1992-907654 19920414
US 5811547 A 19980922 US 1995-416815 19950609
ABSTRACT:
The object of this invention is to provide a process for producing a solid dispersion, which has overcome the disadvantages of the conventional prodn. technol. for solid dispersions. The invention comprises employing a twin-screw extruder in the prodn. of a solid dispersion. In accordance with the invention, a solid dispersion can be expediently produced without heating a drug and a polymer to or beyond their m.ps. and without using an org. solvent for dissolving both components and the resulting solid dispersion has excellent performance characteristics. Indomethacin was blended with hydroxypropyl Me cellulose phthalate and a 50% aq. soln. of tri-Et citrate was added. The compn. was molded by using a twin-screw extruder to provide an extrudate (solid dispersion).
Updated 4/24/2007 1:19:46 PM
