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Home   •   Spotlight  •  rlist4q06j  •  Most Requested Journal Articles 4Q06-Chemistry and Related (8)

Most Requested Journal Articles 4Q06-Chemistry and Related

Following is one of the journal articles most requested by researchers using CAS electronic products.

 

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CAS indexed 70 chemical substances from this document. CAS subject entries for this document include: Epoxidation; Aldol condensation; Alkylation; and 1 additional concept.

CAPLUS COPYRIGHT 2007 ACS on STN

TITLE:	Enantioselective Total Synthesis of Bistramide A
AUTHOR(S):	Crimmins, Michael T.; DeBaillie, Amy C.
CORPORATE SOURCE:	Department of Chemistry, Venable and Kenan Laboratories of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-3290, USA
SOURCE:	Journal of the American Chemical Society (2006), 128(15), 4936-4937 CODEN: JACSAT; ISSN: 0002-7863
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
The enantioselective synthesis of bistramide A (I) has been achieved with a longest linear sequence of 18 steps. The synthetic strategy involves the use of a distereoselective glycolate alkylation, an aldol addn. of a chlorotitanium enolate of N-acylthiazolidinethione II, and a Sharpless asym. epoxidn. to synthesize the three key fragments.