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CAS indexed 436 chemical substances from this document.
CAS subject entries for this document include: Skin, disease; Carbohydrates, biological studies; Hair preparations; and 36 additional concepts. | |
CAPLUS COPYRIGHT 2006 ACS on STN
| TITLE:
| Improved bioavailability and improved delivery of alkaline drugs |
| INVENTOR(S):
| Yu, Ruey J.; Van Scott, Eugene J. |
| PATENT ASSIGNEE(S):
| USA |
| SOURCE:
| PCT Int. Appl., 41 pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2004080468 A1 20040923 WO 2004-US6699 20040305
W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH,
CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD,
GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC,
LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI,
NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY,
TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
RW: BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW, AM, AZ,
BY, KG, KZ, MD, RU, TJ, TM, AT, BE, BG, CH, CY, CZ, DE, DK, EE,
ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI,
SK, TR, BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN,
TD, TG
US 2004214215 A1 20041028 US 2004-792273 20040304
CA 2517782 AA 20040923 CA 2004-2517782 20040305
EP 1601366 A1 20051207 EP 2004-717955 20040305
R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT,
IE, SI, LT, LV, FI, RO, MK, CY, AL, TR, BG, CZ, EE, HU, PL, SK
ABSTRACT:
Embodiments of the invention relate to a compn., a process of making the compn., and to the use of the compn. The compns. include a mol. complex formed between an alk. pharmaceutical and at least one selected from a hydroxyacid, a polyhydroxy acid, a related acid, a lactone, or combinations thereof. The compns. provide improved bioavailability and improved delivery of the drug into the cutaneous tissues. For example, diphenhydramine hydrochloride 29 g (0.1 mol) was dissolved in water (50 mL) and 5N sodium hydroxide (20 mL) was slowly added to generate diphenhydramine as a free base as shown by the formation of oily ppts. and the change from pH 5.5 to 9.4. Gluconolactone 18 g (0.1 mol) was added to form a mol. complex between the diphenhydramine free base and gluconic acid/gluconolactone as shown by the disappearance of the oily ppts. and the change from pH 9.4 to 7.4. The soln. thus obtained contained 0.1 mol diphenhydramine in mol. complex with 0.1 mol gluconic acid/gluconolactone. This concd. stock soln. was used for various forms of topical formulations including oil-in-water creams, lotions, gels and solns.
Updated 5/11/2007 12:51:45 PM
