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Most Requested Journal Articles 4Q05-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS electronic products.

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CAS subject entries for this document include: Arylation; Cyclization; Vinylation; and 5 additional concepts.

CAPLUS COPYRIGHT 2006 ACS on STN

TITLE:	Palladium-catalyzed cross-coupling reactions in total synthesis
AUTHOR(S):	Nicolaou, K. C.; Bulger, Paul G.; Sarlah, David
CORPORATE SOURCE:	Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA
SOURCE:	Angewandte Chemie, International Edition (2005), 44(29), 4442-4489 CODEN: ACIEF5; ISSN: 1433-7851
PUBLISHER:	Wiley-VCH Verlag GmbH & Co. KGaA
LANGUAGE:	English

ABSTRACT:
A review. In studying the evolution of org. chem. and grasping its essence, one comes quickly to the conclusion that no other type of reaction plays as large a role in shaping this domain of science than carbon-carbon bond-forming reactions. The Grignard, Diels-Alder, and Wittig reactions are but three prominent examples of such processes, and are among those which have undeniably exercised decisive roles in the last century in the emergence of chem. synthesis as we know it today. In the last quarter of the 20th century, a new family of carbon-carbon bond-forming reactions based on transition-metal catalysts evolved as powerful tools in synthesis. Among them, the palladium-catalyzed cross-coupling reactions are the most prominent. In this review, highlights of a no. of selected syntheses are discussed. The examples chosen demonstrate the enormous power of these processes in the art of total synthesis and underscore their future potential in chem. synthesis.