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CAPLUS COPYRIGHT 2005 ACS on STN
| TITLE:
| Nanoparticles having oligonucleotides attached on surface and use for detecting nucleic acids |
| INVENTOR(S):
| Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert |
| PATENT ASSIGNEE(S):
| Northwestern University, USA; Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert |
| SOURCE:
| PCT Int. Appl., 144 pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 9804740 A1 19980205 WO 1997-US12783 19970721
W: AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CU, CZ, DE,
DK, EE, ES, FI, GB, GE, GH, HU, IL, IS, JP, KE, KG, KP, KR, KZ,
LC, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL,
PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, UA, UG, US,
UZ, VN, YU, ZW, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM
RW: GH, KE, LS, MW, SD, SZ, UG, ZW, AT, BE, CH, DE, DK, ES, FI, FR,
GB, GR, IE, IT, LU, MC, NL, PT, SE, BF, BJ, CF, CG, CI, CM, GA,
GN, ML, MR, NE, SN, TD, TG
CA 2262018 AA 19980205 CA 1997-2262018 19970721
AU 9740434 A1 19980220 AU 1997-40434 19970721
EP 918885 A1 19990602 EP 1997-938010 19970721
R: CH, DE, ES, FR, GB, IT, LI, SE
JP 2000516460 T2 20001212 JP 1998-508917 19970721
US 6361944 B1 20020326 US 1999-344667 19990625
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US 2002182613 A1 20021205 US 2001-976971 20011012
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US 2004219520 A1 20041104 US 2001-976900 20011012
US 2003044805 A1 20030306 US 2001-981344 20011015
US 6777186 B2 20040817
AU 770201 B2 20040219 AU 2001-87242 20011101
US 2003087242 A1 20030508 US 2001-8978 20011207
US 2003207296 A1 20031106 US 2002-266983 20021008
US 2003180783 A1 20030925 US 2003-410324 20030409
US 2004072231 A1 20040415 US 2003-640618 20030813
US 2004110220 A1 20040610 US 2003-716829 20031118
JP 2004194669 A2 20040715 JP 2004-35790 20040212
ABSTRACT:
Provided are methods of detecting a nucleic acid using nanoparticles having oligonucleotides attached on the surface. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached on the surface. The oligonucleotides attached to nanoparticles have sequences complementary to at least a portion of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. Also provided are compns. and kits comprising nanoparticles made of gold and oligonucleotides labeled with fluorescent mols. The invention further provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing the nanoparticles. A method of sepg. a selected nucleic acid from other nucleic acids is also described.
Updated 5/11/2007 11:43:18 AM
