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CAPLUS COPYRIGHT 2005 ACS on STN
| TITLE:
| Preparation of pyridine-containing diaryl ureas useful in the treatment of cancer and other disorders |
| INVENTOR(S):
| Dumas, Jacques; Lee, Wendy; Chen, Yuanwei; Adnane, Lila; Scott, William J.; Verma, Sharad; Chen, Jianging; Chen, Zhi; Yi, Lin |
| PATENT ASSIGNEE(S):
| Bayer Pharmaceuticals Corporation, USA |
| SOURCE:
| PCT Int. Appl., 96 pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2004078128 A2 20040916 WO 2004-US6295 20040301
WO 2004078128 A3 20041223
W: AE, AE, AG, AL, AL, AM, AM, AM, AT, AT, AU, AZ, AZ, BA, BB, BG,
BG, BR, BR, BW, BY, BY, BZ, BZ, CA, CH, CN, CN, CO, CO, CR, CR,
CU, CU, CZ, CZ, DE, DE, DK, DK, DM, DZ, EC, EC, EE, EE, EG, ES,
ES, FI, FI, GB, GD, GE, GE, GH, GM, HR, HR, HU, HU, ID, IL, IN,
IS, JP, JP, KE, KE, KG, KG, KP, KP, KP, KR, KR, KZ, KZ, KZ, LC,
LK, LR, LS, LS, LT, LU, LV, MA, MD, MD, MG, MK, MN, MW, MX, MX,
MZ, MZ, NA, NI
RW: BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW, AT, BE,
BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU,
MC, NL, PL, PT, RO, SE, SI, SK, TR, BF, BJ, CF, CG, CI, CM, GA,
GN, GQ, GW, ML, MR, NE, SN, TD, TG, BF, BJ, CF, CG, CI, CM, GA,
GN, GQ, GW, ML, MR, NE, SN, TD, TG
ABSTRACT:
The title novel pyridine-contg. diaryl ureas ANHC(O)NHBLMQ [A = (un)substituted Ph, naphthyl, heteroaryl, etc.; B = (un)substituted Ph, naphthyl, pyridyl; L = (CH2)mO(CH2)l, (CH2)m(CH2)l, (CH2)mC(O)(CH2)l, etc.; m, l = 0-4; M = (un)substituted pyridine; Q = tetrazolyl, imidazolyl, thiazolinyl, etc.], useful for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies, were prepd. and formulated. E.g., a multi-step synthesis of I, was given.
Updated 5/11/2007 11:40:26 AM
