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Most Requested Journal Articles 4Q04-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS online services.

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CAS indexed 1 chemical substance from this document. CAS subject entries for this document include: Amines, uses; Asymmetric synthesis and induction; Enamines; and 9 additional concepts.

CAPLUS COPYRIGHT 2005 ACS on STN

TITLE:	Enamine-Based Organocatalysis with Proline and Diamines: The Development of Direct Catalytic Asymmetric Aldol, Mannich, Michael, and Diels-Alder Reactions
AUTHOR(S):	Notz, Wolfgang; Tanaka, Fujie; Barbas, Carlos F., III
CORPORATE SOURCE:	The Skaggs Institute for Chemical Biology and the Departments of Chemistry and Molecular Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA
SOURCE:	Accounts of Chemical Research (2004), 37(8), 580-591 CODEN: ACHRE4; ISSN: 0001-4842
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
A review. Enamines and imines have long been recognized as key intermediates in enzyme catalysis, particularly within a class of enzymes org. chemists would very much like to emulate, the aldolases. Here we summarize the contributions of this lab. to converting enzymic enamines, and in some cases imines, into a versatile catalytic asym. strategy powered by small org. mols.

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