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Home   •   Spotlight  •  rlist4q04j  •  Most Requested Journal Articles 4Q04-Chemistry and Related Science (3)

Most Requested Journal Articles 4Q04-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS online services.

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CAS indexed 74 chemical substances from this document. CAS subject entries for this document include: Cross-coupling reaction; Cross-coupling reaction catalysts; Aryl halides; and 1 additional concept.

CAPLUS COPYRIGHT 2005 ACS on STN

TITLE:	An Extremely Active Catalyst for the Negishi Cross-Coupling Reaction
AUTHOR(S):	Milne, Jacqueline E.; Buchwald, Stephen L.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Journal of the American Chemical Society (2004), 126(40), 13028-13032 CODEN: JACSAT; ISSN: 0002-7863
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides (Negishi coupling) has been developed. This system permits efficient prepn. of hindered biaryls (tri- and tetra-ortho-substituted), functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates. A systematic study of ligand structure was performed and was correlated with catalyst activity.

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