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Most Requested Journal Articles 4Q04-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS online services.

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CAS indexed 8 chemical substances from this document. CAS subject entries for this document include: Oxidation; Solid phase synthesis; Human; and 3 additional concepts.

CAPLUS COPYRIGHT 2005 ACS on STN

TITLE:	Convenient synthesis of human calcitonin and its methionine sulfoxide derivative
AUTHOR(S):	Shi, Tiesheng; Rabenstein, Dallas L.
CORPORATE SOURCE:	Department of Chemistry, University of California, Riverside, CA, 92521, USA
SOURCE:	Bioorganic & Medicinal Chemistry Letters (2002), 12(16), 2237-2240 CODEN: BMCLE8; ISSN: 0960-894X
PUBLISHER:	Elsevier Science Ltd.
LANGUAGE:	English

ABSTRACT:
The human calcitonin peptide chain was assembled using Fmoc solid-phase peptide synthesis chem. The combinations of cleavage Reagent H (TFA 81%, phenol 5%, thioanisole 5%, ethanedithiol 2.5%, dimethylsulfide 2%, water 3%, ammonium iodide 1.5 %) with trans-[Pt(en)2Cl2]2+ and Reagents B (TFA 88%, phenol 5%, triisopropylsilane 2%,and water 5%), K (TFA 82.5%, phenol 5%, thioanisole 5%, ethanedithiol 2.5%, and water 5%), and R (TFA 90%, thioanisole 5%, ethanedithiol 3%, anisole 2%) with trans-[Pt(CN)4Cl2]2- provide convenient methods for the synthesis of human calcitonin and its methionine sulfoxide deriv.; the formation of intramol. disulfide bonds by the above Pt(IV) oxidants is essentially quant.

 

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