• CAS Science Spotlight Home
• Most Requested Documents 4Q02-Chemistry and Related Science
• About
• What's New

Home   •   Spotlight  •  rlist4q02  •  Most Requested Documents 4Q02-Chemistry and Related Science (9)

Most Requested Documents 4Q02-Chemistry and Related Science

Following is one of the documents most requested by researchers using CAS electronic products.

---

CAS indexed 32 chemical substances from this document. CAS subject entries for this document include: Acids, preparation; Group IIIA element compounds.

CAPLUS COPYRIGHT 2003 ACS

TITLE:	An Improved Protocol for the Preparation of 3-Pyridyl- and Some Arylboronic Acids
AUTHOR(S):	Li, Wenjie; Nelson, Dorian P.; Jensen, Mark S.; Hoerrner, R. Scott; Cai, Dongwei; Larsen, Robert D.; Reider, Paul J.
CORPORATE SOURCE:	Process Research Department, Merck Research Laboratories, Rahway, NJ, 07065, USA
SOURCE:	Journal of Organic Chemistry (2002), 67(15), 5394-5397 CODEN: JOCEAH; ISSN: 0022-3263
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
3-Pyridylboronic acid was prepd. in high yield and bulk quantity from 3-bromopyridine via a protocol of Li-halogen exchange and in situ quench. This technique was further studied and evaluated on other aryl halides in the prepn. of arylboronic acids. For example, a 91% yield of 3-thienylboronic acid was obtained using the in situ quench method compared to 55% for a sequential addn. procedure.

View the full-text pdf document from the American Chemical Society, a participating ChemPort publisher.