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Home   •   Spotlight  •  rlist4q02  •  Most Requested Documents 4Q02-Chemistry and Related Science (6)

Most Requested Documents 4Q02-Chemistry and Related Science

Following is one of the documents most requested by researchers using CAS electronic products.

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CAS indexed 106 chemical substances from this document. CAS subject entries for this document include: Amidation; Amidation catalysts; Aryl halides; and 2 additional concepts.

CAPLUS COPYRIGHT 2003 ACS

TITLE:	A General and Efficient Copper Catalyst for the Amidation of Aryl Halides
AUTHOR(S):	Klapars, Artis; Huang, Xiaohua; Buchwald, Stephen L.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Journal of the American Chemical Society (2002), 124(25), 7421-7428 CODEN: JACSAT; ISSN: 0002-7863
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
An exptl. simple and inexpensive catalyst system was developed for the amidation of aryl halides by using 0.2-10 mol % of CuI, 5-20 mol % of a 1,2-diamine ligand, and K3PO4, K2CO3, or Cs2CO3 as base. Catalyst systems based on N,N'-dimethylethylenediamine or trans-N,N'-dimethyl-1,2-cyclohexanediamine were found to be the most active even though several other 1,2-diamine ligands could be used in the easiest cases. Aryl iodides, bromides, and in some cases even aryl chlorides can be efficiently amidated. A variety of functional groups are tolerated in the reaction, including many that are not compatible with Pd-catalyzed amidation or amination methodol.

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