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CAS indexed 64 chemical substances from this document.
CAS subject entries for this document include: Cyclization; Addition reaction; Asymmetric synthesis and induction. | |
CAPLUS COPYRIGHT 2003 ACS
| TITLE:
| Total Synthesis of Ecteinascidin 743 |
| AUTHOR(S):
| Endo, Atsushi; Yanagisawa, Arata; Abe, Masanao; Tohma, Shigemitsu; Kan, Toshiyuki; Fukuyama, Tohru |
| CORPORATE SOURCE:
| Graduate School of Pharmaceutical Sciences, The University of Tokyo, CREST, The Japan Science and Technology Cooperation (JST), Bunkyo-ku, Tokyo, 113-0033, Japan |
| SOURCE:
| Journal of the American Chemical Society (2002), 124(23), 6552-6554 CODEN: JACSAT; ISSN: 0002-7863 |
| PUBLISHER:
| American Chemical Society |
| LANGUAGE:
| English |
ABSTRACT:
The total synthesis of ecteinascidin 743 (I), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's four component coupling reaction, intramol. Heck reaction, phenol-aldehyde cyclization, and acid-induced intramol. sulfide formation.
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Updated 5/11/2007 9:10:47 AM
