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CAS indexed 534 chemical substances from this document.
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CAPLUS COPYRIGHT 2007 ACS on STN
| TITLE:
| Preparation of pyrrolo[2,3-b]pyridines as inhibitors of Akt activity |
| INVENTOR(S):
| Seefeld, Mark Andrew; Hamajima, Toshihiro; Jung, David Kendall; Nakamura, Hiroko; Reid, Paul R.; Reno, Michael John; Rouse, Meagan B.; Heerding, Dirk A.; Tang, Jun; Wang, Jizhou |
| PATENT ASSIGNEE(S):
| Smithkline Beecham Corporation, USA |
| SOURCE:
| PCT Int. Appl., 273pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2007076423 A2 20070705 WO 2006-US62453 20061221
W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH,
CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD,
GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN,
KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK,
MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO,
RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT,
TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
RW: AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE,
IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR, BF, BJ,
CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG, BW, GH,
GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW, AM, AZ, BY,
KG, KZ, MD, RU, TJ, TM
ABSTRACT:
Title compds. represented by the formula I [wherein V = CH or N; Z = CR7 or N; R7 = H, CO2H, CO2-alkyl or alkyl; W, X, Y = independently CR5, CR10 or N; R5 = H, alkyl, aryl, etc.; R10 = substituted thienyl; and pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof] were prepd. as Akt inhibitors. For example, II was provided in a multi-step synthesis starting from the reaction of 3-iodo-1H-pyrrolo[2,3-b]pyridine with benzenesulfonyl chloride. Some of prepd. compds. were tested in the Akt enzyme assay and each exhibited an IC50 value less than or equal to 0.5 .mu.M against Akt1, Akt2 and Akt3. Thus, I and their pharmaceutical compns. are useful as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.
Updated 11/5/2007 2:02:17 PM
