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CAS indexed 2152 chemical substances from this document.
CAS subject entries for this document include: Gene, animal; Neurotrophic factor receptors; Nerve, disease; and 19 additional concepts | |
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CAPLUS COPYRIGHT 2007 ACS on STN
| TITLE:
| Heterocyclic compounds as tyrosine kinase modulators and their preparation, pharmaceutical compositions and use in the treatment of diseases |
| INVENTOR(S):
| Anikin, Alexey Vyacheslavovich; Gantla, Vidyasagar Reddy; Gregor, Vlad Edward; Jiang, Luyong; Liu, Yahua; Mcgee, Danny Peter Claude; Mikel, Charles Chamchoumis; Pickens, Jason Conrad; Webb, Thomas Roy; Zheng, Yan; Zhu, Tong; Kadushkin, Aleksander; Zozulya, Sergey; Chucholowski, Alexander; Mcgrath, Douglas Eric; Sviridov, Sergey |
| PATENT ASSIGNEE(S):
| Chembridge Research Laboratories, Inc., USA |
| SOURCE:
| PCT Int. Appl., 385pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2007056155 A1 20070518 WO 2006-US42982 20061102
W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH,
CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD,
GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN,
KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK,
MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO,
RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT,
TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
RW: AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE,
IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR, BF, BJ,
CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG, BW, GH,
GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW, AM, AZ, BY,
KG, KZ, MD, RU, TJ, TM
ABSTRACT:
The invention provides compds. of formula I and related compds., capable of modulating tyrosine kinases, compns. comprising the compds. and methods of their use. Compds. of formula I wherein R1 is (un)substituted heterocyclyl, (un)substituted alkyl, (un)substituted sulfonyl, acyl, etc.; R2 is H, lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkylalkyl, (un)substituted (hetero)aryl(alkyl), heterocycloalkyl, etc.; Q1, Q2, Q3 and Q4 are independently. C1-5 alkyl; and their stereoisomers, tautomers, salts, hydrates and prodrugs thereof, are claimed. Example compd. II was prepd. by amidation of 2-[2-hydroxy-5-(2-methoxypyridin-3-yl)phenyl]benzimidazole-5-carboxylic acid with 1-methoxy-2-propylamine. All the invention compds. were evaluated for their tyrosine kinase modulatory activity (some data given).
Updated 11/5/2007 1:59:02 PM
