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Most Requested Journal Articles 3Q07-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS electronic products.

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CAS subject entries for this document include: Cyclocondensation reaction; Rearrangement; Aldol condensation catalysts; and 22 additional concepts.

CAPLUS COPYRIGHT 2007 ACS on STN

TITLE:	Recent advances in asymmetric phase-transfer catalysis
AUTHOR(S):	Ooi, Takashi; Maruoka, Keiji
CORPORATE SOURCE:	Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, 606-8502, Japan
SOURCE:	Angewandte Chemie, International Edition (2007), 46(23), 4222-4266 CODEN: ACIEF5; ISSN: 1433-7851
PUBLISHER:	Wiley-VCH Verlag GmbH & Co. KGaA
LANGUAGE:	English

ABSTRACT:
A review. The use of chiral non-racemic onium salts and crown ethers as effective phase-transfers catalysts were studied intensively primarily for enantioselective carbon-carbon or carbon-heteroatom bond-forming reactions under mild biphasic conditions. An essential issue for optimal asym. catalysis is the rational design of catalysts for targeted reaction, which allows generation of a well-defined chiral ion pair that reacts with electrophiles in a highly efficient and stereoselective manner. This concept, together with the synthetic versatility of phase-transfer catalysis, provides a reliable and general strategy for the practical asym. synthesis of highly valuable org. compds.