Following is one of the patent documents most requested by researchers using CAS electronic products.
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CAS indexed 66 chemical substances from this document.
CAS subject entries for this document include: Heart, disease; Autoimmune disease; Diabetes mellitus; and 25 additional concepts. | |
CAPLUS COPYRIGHT 2006 ACS on STN
| TITLE:
| Preparation of substituted indazole-O-glucosides as antidiabetic agents and for treatment of Syndrome X |
| INVENTOR(S):
| Patel, Mona; Rybczynski, Philip; Urbanski, Maud; Zhang, Xiaoyan |
| PATENT ASSIGNEE(S):
| Janssen Pharmaceutica N.V., Belg.; Tanabe Seiyaku Co., Ltd |
| SOURCE:
| PCT Int. Appl., 88 pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2005011592 A2 20050210 WO 2004-US24626 20040729
WO 2005011592 A3 20050616
W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH,
CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD,
GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC,
LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI,
NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY,
TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
RW: BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW, AM,
AZ, BY, KG, KZ, MD, RU, TJ, TM, AT, BE, BG, CH, CY, CZ, DE, DK,
EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE,
SI, SK, TR, BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE,
SN, TD, TG
CA 2549017 AA 20050210 CA 2004-2549017 20040729
EP 1680414 A2 20060719 EP 2004-779629 20040729
R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LI, LU, NL, SE, MC, PT,
IE, SI, LT, LV, FI, RO, MK, CY, AL, TR, BG, CZ, EE, HU, PL, SK, HR
US 2005032711 A1 20050210 US 2004-903034 20040730
US 7084124 B2 20060801
US 2006217323 A1 20060928 US 2006-446014 20060602
US 2006229260 A1 20061012 US 2006-453728 20060615
ABSTRACT:
Substituted indazole-O-glucosides I, wherein R is H, acetyl; R1 is H, alkyl; R2 is H, F, Cl, OMe, alkyl; Q is CH2S, (CH2)n; n is 0-2; Z is fused bicyclyl, fused heterocyclyl, were prepd. for the treatment of diabetes and Syndrome X. A process is claimed for making a pharmaceutical compn. comprising mixing one or more title compds. in combination with a second antidiabetic agent for the prepn. of a medicament for treating a condition selected from IDDM, NIDDM, IGT, IFG, obesity, nephropathy, neuropathy, retinopathy, atherosclerosis, polycystic ovarian syndrome, hypertension, ischemia, stroke, heart disease, irritable bowel disorder, inflammation, and cataracts. Thus, glycoside II was prepd. and tested in mice as antidiabetic agent.
Updated 5/11/2007 8:56:56 AM
