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CAS indexed 970 chemical substances from this document.
CAS subject entries for this document include: Fungicides; Mycosis. | |
CAPLUS COPYRIGHT 2005 ACS on STN
| TITLE:
| Preparation of heterocyclic compounds as antifungal agents |
| INVENTOR(S):
| Nakamoto, Kazutaka; Tsukada, Itaru; Tanaka, Keigo; Matsukura, Masayuki; Haneda, Toru; Inoue, Satoshi; Ueda, Norihiro; Abe, Shinya; Hata, Katsura; Watanabe, Naoaki |
| PATENT ASSIGNEE(S):
| Eisai Co., Ltd., Japan |
| SOURCE:
| PCT Int. Appl., 418 pp. CODEN: PIXXD2 |
| LANGUAGE:
| Japanese |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2005033079 A1 20050414 WO 2004-JP14063 20040927
W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH,
CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD,
GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC,
LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI,
NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY,
TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
RW: BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW, AM,
AZ, BY, KG, KZ, MD, RU, TJ, TM, AT, BE, BG, CH, CY, CZ, DE, DK,
EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE,
SI, SK, TR, BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE,
SN, TD, TG
ABSTRACT:
The title compds., e.g. I [ring A1 is optionally substituted 3-pyridyl, optionally substituted quinolyl, etc.; X1 is NHCO, etc.; and ring E is furyl, thienyl, pyrrolyl, Ph, pyridyl, tetrazolyl, thiazolyl, or pyrazolyl; provided that A1 may have one to three substituents and E has one or two substituents], are prepd. 2,6-Diamino-N-(5-(4-fluorophenoxy)furan-2-ylmethyl)nicotinamide was prepd. in a multistep process. Compds. of this invention in vitro showed MIC values of 0.1 .mu.g/mL to 6.25 .mu.g/mL against Candida.
Updated 5/10/2007 1:09:01 PM
