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Most Requested Journal Articles 3Q05-Chemistry and Related Science
Following is one of the journal articles most requested by researchers using CAS electronic products.
CAPLUS COPYRIGHT 2005 ACS on STN
Cheap, readily available, air stable, nontoxic, and environmentally benign iron salts such as Fe(acac)3 are excellent precatalysts for the cross-coupling of Grignard reagents with alkenyl triflates and acid chlorides. Moreover, it is shown that dichloroarene and -heteroarene derivs. as the substrates can be selectively monoalkylated by this method. All cross-coupling reactions proceed very rapidly under notably mild conditions and turned out to be compatible with a variety of functional groups in both reaction partners. A detailed anal. of the preparative results suggests that iron-catalyzed C-C bond formations can occur via different pathways. Thus, it is likely that reactions of methylmagnesium halides involve iron-ate complexes as the active components, whereas reactions of Grignard reagents with two or more carbon atoms are effected by highly reduced iron-clusters of the formal compn. [Fe(MgX)2]n generated in situ. Control expts. using the ate-complex [Me4Fe]Li2 [i.e., dilithium tetramethylferrate(2-) dietherate] corroborate this interpretation. View full-text pdf document from the American Chemical Society, a participating ChemPort publisher. Updated 5/10/2007 9:23:20 AM
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