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Most Requested Journal Articles 3Q05-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS electronic products.

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CAS indexed 112 chemical substances from this document. CAS subject entries for this document include: Hydrogenation; Hydrogenation catalysts; Ligands; and 4 additional concepts.

CAPLUS COPYRIGHT 2005 ACS on STN

TITLE:	Transfer Hydrogenation of Activated C:C Bonds Catalyzed by Ruthenium Amido Complexes: Reaction Scope, Limitation, and Enantioselectivity
AUTHOR(S):	Xue, Dong; Chen, Ying-Chun; Cui, Xin; Wang, Qi-Wei; Zhu, Jin; Deng, Jin-Gen
CORPORATE SOURCE:	Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, Peop. Rep. China
SOURCE:	Journal of Organic Chemistry (2005), 70(9), 3584-3591 CODEN: JOCEAH; ISSN: 0022-3263
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
It was found that the chemoselectivity could be completely switched from C:O to C:C bonds in the transfer hydrogenation of activated .alpha.,.beta.-unsatd. ketones R1CH:CR2COR3 (R1 = Ph, 4-MeOC6H4, 4-O2NC6H4; R2 = H, Me, MeCO, EtO2C; R3 = Me, Ph) catalyzed by diamine-ruthenium complex. Moreover, this addn. via metal hydride had been applied to the redn. of various activated olefins R4R5C:CR6R7 (R4 = H, Me; R5 = H, n-C5H11, Ph, 4-MeOC6H4, 4-O2NC6H4; R6 = CN, EtO2C, Ph, O2N, etc.; R7 = H, CN, O2N, HO2C, etc.). The electron-withdrawing ability of functional groups substituted on C:C bonds at the .alpha.- or .beta.-position had strong influence on the reactivity. In addn., a wide variety of chiral diamine-Ru(II)(arene) systems was investigated to explore the asym. transfer hydrogenation of prochiral .alpha.,.alpha.-dicyanoolefins. Two parameters had been systematically studied: (i) the structure of the N-sulfonylated chiral diamine ligands and (ii) the structure of the metal precursors.

 

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