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CAPLUS COPYRIGHT 2004 ACS on STN
| TITLE:
| Preparation of pyrazole derivatives as inhibitors of mitogen activated protein kinase-activated protein kinase-2 |
| INVENTOR(S):
| Hanau, Cathleen E.; Mershon, Serena Marie; Graneto, Matthew J.; Meyers, Marvin J.; Hegde, Shridhar G.; Buchler, Ingrid P.; Wu, Kun K.; Liu, Shuang; Nacro, Kassoom |
| PATENT ASSIGNEE(S):
| Pharmacia Corporation, USA |
| SOURCE:
| PCT Int. Appl., 265 pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2004058176 A2 20040715 WO 2003-US40932 20031219
WO 2004058176 A3 20040916
W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH,
CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD,
GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC,
LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO,
NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ,
TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW, AM,
AZ, BY, KG, KZ
RW: BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW, AT, BE,
BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU,
MC, NL, PT, RO, SE, SI, SK, TR, BF, BJ, CF, CG, CI, CM, GA, GN,
GQ, GW, ML, MR, NE, SN, TD, TG
US 2004152739 A1 20040805 US 2003-742494 20031219
ABSTRACT:
Title compds. were prepd. as inhibitors of mitogen activated protein kinase-activated protein kinase-2 (MK-2). Thus, the title compd. I was prepd. in a multi-step synthesis and had IC50 for MK-2 inhibition of 0.0269 .mu.M.
Updated 5/9/2007 2:47:42 PM
