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Most Requested Journal Articles 3Q04-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS online services.

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CAS indexed 86 chemical substances from this document. CAS subject entries for this document include: Coupling reaction; Coupling reaction catalysts; Alkyl bromides; and 2 additional concepts.

CAPLUS COPYRIGHT 2004 ACS on STN

TITLE:	Palladium-Catalyzed Negishi Cross-Coupling Reactions of Unactivated Alkyl Iodides, Bromides, Chlorides, and Tosylates
AUTHOR(S):	Zhou, Jianrong; Fu, Gregory C.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Journal of the American Chemical Society (2003), 125(41), 12527-12530 CODEN: JACSAT; ISSN: 0002-7863
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
A single method (2% Pd2(dba)3/8% PCyp3/NMI (NMI = N-methylimidazole) in THF/NMP at 80 .degree.C; Cyp = cyclopentyl) achieves the cross-coupling of a range of .beta.-hydrogen-contg. primary alkyl iodides, bromides, chlorides, and tosylates with an array of alkyl-, alkenyl-, and arylzinc halides. E.g., Pd2(dba)3/8% PCyp3/NMI catalyzed the coupling reaction of BnO(CH2)3Br with BuZnBr to give 70% BnO(CH2)3Bu. The process is compatible with a variety of functional groups, including esters, amides, imides, nitriles, and heterocycles.

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