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Home   •   Spotlight  •  rlist3q02  •  Most Requested Documents 3Q02-Chemistry and Related (9)

Most Requested Documents 3Q02-Chemistry and Related

Following is one of the documents most requested by researchers using CAS electronic products.

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CAS indexed 70 chemical substances from this document. CAS subject entries for this document include: Iodides, reactions; Amination catalysts; Amines, reactions; and 2 additional concepts.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	Copper-Catalyzed Coupling of Alkylamines and Aryl Iodides: An Efficient System Even in an Air Atmosphere
AUTHOR(S):	Kwong, Fuk Yee; Klapars, Artis; Buchwald, Stephen L.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Organic Letters (2002), 4(4), 581-584 CODEN: ORLEF7; ISSN: 1523-7060
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
A mild method for the copper-catalyzed amination of aryl iodides is reported. This operationally simple C-N bond-forming protocol uses CuI as the catalyst and ethylene glycol as ligand in 2-propanol. A variety of functionalized aryl iodides as well as several amines were efficiently coupled using this method. This catalytic amination procedure is relatively insensitive to moisture and can be performed under an air atm. with comparable yield. Preliminary results on the amination of aryl bromides are also described.

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