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Most Requested Documents 3Q02-Chemistry and Related

Following is one of the documents most requested by researchers using CAS electronic products.

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CAS indexed 23 chemical substances from this document. CAS subject entries for this document include: Alkenes, reactions; Hydroxylation catalysts; Addition reaction catalysts.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	A new approach to osmium-catalyzed asymmetric dihydroxylation and aminohydroxylation of olefins
AUTHOR(S):	Andersson, Malin A.; Epple, Robert; Fokin, Valery V.; Sharpless, K. Barry
CORPORATE SOURCE:	Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA
SOURCE:	Angewandte Chemie, International Edition (2002), 41(3), 472-475 CODEN: ACIEF5; ISSN: 1433-7851
PUBLISHER:	Wiley-VCH Verlag GmbH
LANGUAGE:	English

ABSTRACT:
The title reactions were carried out with ligands contg. vicinal hydroxy and tosylamino groups, e.g., (2S,3R)-MeCH(OH)CH(NHTs)CO2H (I). Styrene and alkyl cinnamates were used as starting olefins. In the case of Me p-nitrocinnamate dihydroxylation using OsO4 with 4-methylmorpholine N-oxide as reoxidant and ligand I, the dihydroxy product was obtained in 70% ee.

View the full-text document from Wiley InterScience.