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Most Requested Documents 3Q02-Chemistry and Related

Following is one of the documents most requested by researchers using CAS electronic products.

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CAS indexed 45 chemical substances from this document. CAS subject entries for this document include: Amines, preparation; Coupling reaction; Coupling reaction catalysts; and 2 additional concepts.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	Improved Functional Group Compatibility in the Palladium-Catalyzed Synthesis of Aryl Amines
AUTHOR(S):	Harris, Michele C.; Huang, Xiaohua; Buchwald, Stephen L.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Organic Letters (2002), 4(17), 2885-2888 CODEN: ORLEF7; ISSN: 1523-7060
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
The use of Pd2dba3 with bulky, electron-rich ligands and LiN(TMS)2 as the base for the coupling of amines with aryl halides contg. hydroxyl, amide, or enolizable keto groups is described. This protocol expands the utility of palladium-catalyzed C-N bond formation by allowing for the use of aryl halides contg. these functional groups, obviating the need for protecting group manipulations.