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Most Requested Documents 3Q02-Chemistry and Related

Following is one of the documents most requested by researchers using CAS electronic products.

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CAS indexed 80 chemical substances from this document. CAS subject entries for this document include: Stille coupling reaction; Aryl bromides; Aryl halides; and 1 additional concept.

CAPLUS COPYRIGHT 2002 ACS

TITLE:	Pd/P(t-Bu)3: A Mild and General Catalyst for Stille Reactions of Aryl Chlorides and Aryl Bromides
AUTHOR(S):	Littke, Adam F.; Schwarz, Lothar; Fu, Gregory C.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Journal of the American Chemical Society (2002), 124(22), 6343-6348 CODEN: JACSAT; ISSN: 0002-7863
PUBLISHER:	American Chemical Society
LANGUAGE:	English

ABSTRACT:
Pd/P(t-Bu)3 serves as an unusually reactive catalyst for Stille reactions of aryl chlorides and bromides, providing solns. to a no. of long-standing challenges. An unprecedented array of aryl chlorides can be cross-coupled with a range of organotin reagents, including SnBu4. Very hindered biaryls (e.g., tetra-ortho-substituted) can be synthesized, and aryl chlorides can be coupled in the presence of aryl triflates. The method is user-friendly, since a com. available complex, Pd(P(t-Bu)3)2, is effective. Pd/P(t-Bu)3 also functions as an active catalyst for Stille reactions of aryl bromides, furnishing the first general method for room-temp. cross-couplings.

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