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Home   •   Spotlight  •  rlist2q07j  •  Most Requested Journal Articles 2Q07-Chemistry and Related Science (7)

Most Requested Journal Articles 2Q07-Chemistry and Related Science

Following is one of the journal articles most requested by researchers using CAS electronic products.

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CAS indexed 70 chemical substances from this document. CAS subject entries for this document include: Amination; Amination catalysts; Ligands; and 4 additional concepts.

CAPLUS COPYRIGHT 2007 ACS on STN

TITLE:	Monodentate phosphines provide highly active catalysts for Pd-catalyzed C-N bond-forming reactions of heteroaromatic halides/amines and (H)N-heterocycles
AUTHOR(S):	Anderson, Kevin W.; Tundel, Rachel E.; Ikawa, Takashi; Altman, Ryan A.; Buchwald, Stephen L.
CORPORATE SOURCE:	Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA
SOURCE:	Angewandte Chemie, International Edition (2006), 45(39), 6523-6527 CODEN: ACIEF5; ISSN: 1433-7851
PUBLISHER:	Wiley-VCH Verlag GmbH & Co. KGaA
LANGUAGE:	English

ABSTRACT:
Highly reactive catalysts based on palladium and dialkylbiarylphosphino ligands provide unprecedented reactivity and selectivity in C-N bond-forming processes. The bulky monophosphine catalyst system Pd2(dba)3/I is effective for the reaction of aryl/heteroaryl halides bearing primary amides and 2-aminoheterocycles, thus showing that monodentate phosphines are viable alternatives to, and sometimes superior to, chelating ligands. E.g., amination of 3-chlorobenzamide by morpholine gave 81% II.