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Most Requested Journal Articles 2Q07-Chemistry and Related Science
Following is one of the journal articles most requested by researchers using CAS electronic products.
CAPLUS COPYRIGHT 2007 ACS on STN
The field of org. synthesis has made phenomenal advances in the past fifty years, yet chemists still struggle to design synthetic routes that will enable them to obtain sufficient quantities of complex mols. for biol. and medical studies. Total synthesis is therefore increasingly focused on prepg. natural products in the most efficient manner possible. Here we describe the preparative-scale, enantioselective, total syntheses of members of the hapalindole, fischerindole, welwitindolinone and ambiguine families, each constructed without the need for protecting groups-the use of such groups adds considerably to the cost and complexity of syntheses. As a consequence, mols. that have previously required twenty or more steps to synthesize racemically in milligram amts. can now be obtained as single enantiomers in significant quantities in ten steps or less. Through the extension of the general principles demonstrated here, it should be possible to access other complex mol. architectures without using protecting groups. Updated 8/24/2007 12:24:42 PM
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