Following is one of the patent documents most requested by researchers using CAS electronic products.
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CAS indexed 12 chemical substances from this document.
CAS subject entries for this document include: Gene, animal; Proteins, specific or class; Nucleic acid amplification (method); and 17 additional concepts. | |
CAPLUS COPYRIGHT 2005 ACS on STN
| TITLE:
| RT-PCR detection of gene expression in blood for disease diagnosis and prognosis |
| INVENTOR(S):
| Liew, Choong-Chin |
| PATENT ASSIGNEE(S):
| Can. |
| SOURCE:
| PCT Int. Appl., 129 pp. CODEN: PIXXD2 |
| LANGUAGE:
| English |
PATENT INFORMATION: PATENT NO. KIND DATE APPLICATION NO. DATE
--------------- ---- -------- -------------------- --------
WO 2000040749 A2 20000713 WO 2000-CA5 20000105
WO 2000040749 A3 20010719
W: AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU,
CZ, DE, DK, DM, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL,
IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA,
MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI,
SK, SL, TJ, TM, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZW, AM,
AZ, BY, KG, KZ, MD, RU, TJ, TM
RW: GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW, AT, BE, CH, CY, DE,
DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE, BF, BJ, CF,
CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG
CA 2359816 AA 20000713 CA 2000-2359816 20000105
ABSTRACT:
The present invention is directed to detection and measurement of gene transcripts in blood. Specifically provided is a RT-PCR anal. performed on a drop of blood for detecting, diagnosing and monitoring diseases using tissue-specific primers. The present invention also describes methods by which delineation of the sequence and/or quantitation of the expression levels of disease-assocd. genes allows for an immediate and accurate diagnostic/prognostic test for disease or to assess the effect of a particular treatment regimen. The quantitation is performed by mass spectrometry. The method involves generation and screening of expressed sequence tags (ETS) and cDNA libraries using gene or disease-specific primers or probes. Single nucleotide polymorphism anal. can be used to monitor the changes in gene expression. The method was applied to the detection of gene expression for insulin, atrial natriuretic factor, zinc finger protein, beta-myosin heavy chain, amyloid precursor protein, and adenomatous polyposis-coil protein in the blood.
Updated 5/8/2007 11:03:34 AM
